The players listed below could provide difference-making stats for DraftKings participants on Monday.
Carlos Gonzalez: As a big leaguer, Gonzalez has posted a game-changing .304/.368/.568 slash line against right-handers. The outfielder could excel at hitter-friendly Great American Ball Park when he faces righty Dan Straily (career 4.56 ERA, 1.30 WHIP).
Gerardo Parra: As a big leaguer, Parra has registered a .768 OPS against right-handers in comparison to a .598 mark vs. lefties. The outfielder could excel against Straily (career 4.77 FIP) and a Reds relief corps that lacks reliable options.
Joey Votto: The first baseman has used his elite mix of power and patience to post a lifetime .316/.433/.546 slash line against right-handers. Votto -- who logged an impressive .362/.535/.617 slash line in the second half of 2015 -- could post a notable total in DraftKings contests when he bats at his hitter-friendly home park against Rockies righty Jordan Lyles (career 5.18 ERA, 1.45 WHIP).
Jay Bruce: Much of Bruce's powerful track record centers around his lifetime .257/.329/.481 slash line against right-handers. The outfielder could drive in multiple runs when he bats at his offense-inducing home park against Lyles (6.00 ERA, 1.60 WHIP since the outset of 2015) and a Rockies relief corps that lacks a reliable bridge to closer Jake McGee and finished last in baseball in 2015 with a 4.70 ERA.
Avisail Garcia: Hitting at his offense-inducing home park, Garcia could have a terrific game when he brings his lifetime .763 OPS against left-handers (.670 vs. righties) into a matchup with Angels southpaw Hector Santiago (career 1.32 WHIP). As a big leaguer, Santiago has allowed right-handed hitters such as Garcia to produce a .746 OPS (.623 OPS allowed to lefty batters).
Todd Frazier: The right-handed-hitting third baseman could make good use of homer-happy U.S. Cellular Field when he brings his lifetime .830 OPS against left-handers (.763 vs. righties) into a matchup with the southpaw Santiago (career 4.53 FIP).
Scooter Gennett: Gennett has produced some of the most lopsided splits in baseball, with an .801 OPS against right-handers that exceeds his .355 mark vs. lefties. The second baseman could reach base often or score multiple runs when he faces Twins righty Phil Hughes (career 4.33 ERA, 1.28 WHIP).
Chris Carter: With 93 homers since the outset of 2013, Carter has become one of the most powerful hitters in baseball. The first baseman could rip a round-tripper when he faces Hughes, who owns a career 1.2 HR/9 rate and registered a 1.7 mark in 2015. Carter could be helped by hitting at Target Field, which is a homer-enhancing venue for right-handed hitters.
Miguel Sano: Since making his big league debut on July 2, 2015, Sano has posted an .865 OPS against right-handers. The outfielder could rip a round-tripper when he faces Chase Anderson (career 4.01 ERA, 1.31 WHIP) at Target Field, which promotes power for right-handed sluggers such as Sano.
Denard Span: Hitting out of the leadoff spot, the outfielder could spark a deep Giants lineup when he brings his lifetime .761 OPS against right-handers (.709 vs. lefties) into a matchup with D-backs righty Archie Bradley (career 5.80 ERA, 1.63 WHIP).
Carlos Rodon: One of the most talented young pitchers in baseball, Rodon has produced a 1.73 ERA and a 1.11 WHIP since Aug. 11, 2015. The left-hander -- who owns a lifetime 8.9 K/9 rate -- could post a notable total in DraftKings contests when he faces an Angels lineup that contains few players who do their best work against southpaws.
Jose Fernandez: With a lifetime 2.49 ERA, 1.02 WHIP and 10.6 K/9 rate, Fernandez is among the most dominant starters in baseball. The right-hander could post a game-changing total in DraftKings contests when he works at his pitcher-friendly home park against the Nationals.
Noah Syndergaard: Syndergaard could excel in a matchup against a Phillies lineup that includes just one player (Ryan Howard) who hit at least 15 homers last season. With a 3.04 ERA, a 1.04 WHIP and a 10.3 K/9 rate since making his big league debut on May 12, 2015, the righty has the skills to post a difference-making total in DraftKings contests.
All statistics are accurate through the completion of Saturday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB. This story was not subject to the approval of Major League Baseball or its clubs.