MLB.com Columnist

Fred Zinkie

Beasts of the East could open weekend hot

Harper, Big Papi set to excel during series-opening matchups

Beasts of the East could open weekend hot

Welcome to DraftKings fantasy baseball, the Official Daily Fantasy Game of Major League Baseball.

The players listed below could provide difference-making stats for DraftKings participants today.

Bryce Harper: Arguably the best hitter in baseball, Harper has posted a .327/.458/.648 slash line since the outset of 2015. The outfielder could post a game-changing total in DraftKings contests when he brings his lifetime .954 OPS against right-handers (.789 vs. lefties) into a matchup with righty Jeremy Hellickson (4.76 ERA, 1.34 WHIP since the outset of 2013) at hitter-friendly Citizens Bank Park.

Daniel Murphy: In his career, Murphy has produced a .787 OPS against right-handers that exceeds his .683 mark vs. lefties. The second baseman could drive in multiple runs when travels to an offense-inducing venue to face the righty Hellickson (4.62 ERA, 1.33 WHIP in 2015) and a Phillies bullpen that lacks reliable options.

Justin Bour: The first baseman owns lopsided lifetime splits, with an .822 OPS against right-handers that exceeds his .594 mark vs. lefties. Bour could drive in multiple runs when he faces Braves righty Williams Perez (career 4.90 ERA, 1.54 WHIP).

Christian Yelich: Hitting out of the three-hole, Yelich could reach base often or score multiple runs when he faces Perez (career 5.05 FIP) and an unsettled Braves bullpen that ranked 29th in the Majors in 2015 with a 4.67 ERA. In his career, Yelich has registered an .808 OPS against right-handers in comparison to a .701 mark vs. lefties.

Yelich's solo blast

Dee Gordon: With balanced career splits, Gordon -- who hit .333 with 58 steals in 2015 -- has the plate skills to thrive against Perez and the Atlanta relief corps. The second baseman could also steal a base against A.J. Pierzynski or Tyler Flowers, as both catchers were among the top-10 in steals allowed last season.

Craig Gentry: Gentry has long fared best vs. left-handers, against whom he has produced a lifetime .719 OPS (.631 vs. lefties). The outfielder could be a cost-effective option for DraftKings participants when he tangles with Twins southpaw Tommy Milone (career 4.24 FIP, 1.30 WHIP). He could also swipe a base against Kurt Suzuki, who allowed more steals than all but two catchers in 2015.

Prince Fielder: From the heart of the Ranges lineup, Fielder could display his power when he brings his lifetime .957 OPS against right-handers (.788 vs. lefties) into a matchup at his hitter-friendly home park against Orioles righty Vance Worley (career 1.39 WHIP).

Nomar Mazara: Since arriving to the Majors on April 10, Mazara -- who posted a .296/.366/.443 slash line in the Minors in 2015 -- has produced a .375/.389/.563 slash line. The left-handed-hitting outfielder could use his strong plate skills and premium lineup spot to reach base often or score multiple runs against Worley.

Zinkie on Choo, Mazara

Matt Wieters: Wieters will be poised to provide production at a premium position when he takes his lifetime .817 OPS against left-handers (.711 vs. righties) into a matchup with Rangers southpaw Martin Perez (career 4.19 ERA, 1.40 WHIP).

Mark Trumbo: The outfielder could display his power at hitter-friendly Globe Life Park in Arlington when he brings his lifetime .828 OPS against left-handers (.735 vs. righties) into a matchup with the lefty Perez. In his career, Perez has allowed right-handed hitters such as Trumbo to post a .768 OPS (.659 OPS allowed to lefty batters).

Colby Rasmus: Having hit 28 homers since the outset of the 2015 season, Rasmus could go deep or drive in multiple runs when he hits at home against Tigers right-hander Mike Pelfrey (career 4.55 ERA, 1.49 WHIP). As a big leaguer, the outfielder owns a lifetime .790 OPS against right-handers that exceeds his .675 mark vs. lefties.

Jason Castro: The catcher has produced pronounced career splits, with a .750 OPS against right-handers in comparison to a .544 mark vs. lefties. Set to hit at home against the right-handed Pelfrey, Castro will be in position to provide DraftKings participants with cost-effective production at a premium position.

David Ortiz: In his prolific career, Ortiz has logged an impressive .293/.396/.580 slash line against right-handers. Having produced a .324/.402/.710 slash line since the All-Star break in 2015, the slugger will be poised to reach base often or display his power when he faces Blue Jays right-hander R.A. Dickey (4.45 FIP in 2015).

Wei-Yin Chen: Despite dealing with hitter-friendly Camden Yards and deep American League lineups, Chen produced a 3.72 ERA across four seasons with the Orioles. The left-hander could thrive in the Senior Circuit, and he will be primed to spin a gem when he works at home against a Braves lineup that does not include a single player who homered 20 times last season.

Zinkie picks two-start pitchers

Carlos Martinez: In 2015, the right-hander produced a 3.01 ERA across his first season working primarily as a starter. Working at home and in front of a Cardinals squad that won 100 games a year ago, Martinez could post a significant total in DraftKings contests when he faces the Reds in a seemingly advantageous matchup with righty Tim Melville.

Zack Greinke: DraftKings participants may avoid Greinke due to his season-to-date 9.90 ERA, but the right-hander -- who posted a 1.66 ERA and a 0.84 WHIP in 2015 -- could get his campaign on track when he travels to pitcher-friendly Petco Park to face the Padres. San Diego's lineup possesses just one player (Matt Kemp) who exceeded the 15-homer mark last year.

Clayton Kershaw: The consensus choice as the most dominant pitcher in baseball, Kershaw has produced a 1.90 ERA, a 0.88 WHIP and a 10.4 K/9 rate since the outset of 2013. The left-hander could be worth a major expenditure in DraftKings contests when he works at his pitcher-friendly home park against the Giants.

All statistics are accurate through the completion of Wednesday's games.

Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB This story was not subject to the approval of Major League Baseball or its clubs.