The players listed below could provide difference-making stats for DraftKings participants on Friday.
Corey Dickerson: The outfielder has produced pronounced career splits, with a .934 OPS against right-handers that exceeds his .669 mark vs. lefties. Dickerson could hit a homer or drive in multiple runs when he travels to hitter-friendly Camden Yards to tangle with righty Chris Tillman (career 4.19 ERA, 1.31 WHIP).
Brad Miller: The shortstop could provide production at a premium position when he faces Tillman (4.99 ERA, 1.39 WHIP in 2015) at an offense-inducing road venue. In his career, Miller has produced a .748 OPS against right-handers in comparison to a .574 mark vs. lefties.
Kevin Kiermaier: As a big leaguer, Kiermaier has registered a .792 OPS against right-handers that notably exceeds his .581 mark vs. lefties. The outfielder could be part of a Rays stack -- including Dickerson, Miller and first baseman Logan Morrison -- against Tillman (career 4.50 FIP).
John Jaso: From an expected perch atop the lineup, Jaso could maximize his opportunities to reach base and score runs when he faces Reds right-hander Alfredo Simon (career 4.17 ERA, 1.34 WHIP) at offense-inducing Great American Ball Park. Jaso owns a lifetime .796 OPS against right-handers that dwarfs his .542 mark vs. lefties.
Gregory Polanco: The speedy outfielder could contribute in multiple ways when he brings his lifetime .272/.344/.407 slash line against right-handers into a matchup with Simon (5.05 ERA, 1.44 WHIP in 2015). Polanco could also excel late in the game against a Reds relief corps that lacks reliable options.
Shin-Soo Choo: Choo got his career back on track when he posted an impressive .343/.455/.560 slash line in the second half of 2015. The outfielder will be poised to display his power when he brings his lifetime .300/.403/.504 slash line against right-handers into a matchup with Angels fly-ball-prone righty Matt Shoemaker (4.46 ERA, 1.6 HR/9 rate in 2015).
Prince Fielder: The slugger could put a ball into the outfield seats when he faces Shoemaker, who owns a lifetime 1.2 HR/9 rate. In his career, Fielder has logged a .959 OPS against right-handers in comparison to a .790 mark vs. lefties.
Daniel Nava: Nava will be set to thrive when he brings his lifetime .281/.377/.409 slash line against right-handers into a matchup with Rangers righty A.J. Griffin (career 4.34 FIP). Griffin will be making his first start since the 2013 season, after recovering from multiple arm injuries.
Denard Span: From his perch atop the lineup, the outfielder will maximize his chances to succeed when he brings his lifetime .761 OPS against right-handers (.715 vs. lefties) into a matchup with Dodgers right-hander Ross Stripling. The 26-year-old will be making his first big league start, and he has yet to pitch at the Triple-A level.
Matt Duffy: Since the outset of his stellar 2015 rookie season, Duffy has posted a .308/.345/.462 slash line against right-handers. The third baseman could be part of a high-scoring lineup when the Giants meet up with the inexperienced Stripling.
Adrian Gonzalez: Gonzalez could drive in multiple runs from the heart of the lineup when he brings his lifetime .298/.375/.527 slash line against right-handers into a matchup with the Giants' Matt Cain, who logged a 5.79 ERA and a 1.50 WHIP in an injury-affected 2015 campaign.
Justin Turner: Since joining the Dodgers at the outset of the 2014 season, Turner has hit .313 with a .382 on-base percentage. The third baseman could use his plate skills to reach base often or score multiple runs when he puts his lifetime .799 OPS against right-handers (.713 vs. lefties) on the line against Cain (5.54 FIP in 2015).
Cory Spangenberg: Now with a full-time gig at second base, Spangenberg will be in position to excel when he brings his career .733 OPS against right-handers (.679 vs. lefties) to hitter-friendly Coors Field. Spangenberg will take on righty Jordan Lyles, who owns a lifetime 5.10 ERA and a 1.44 WHIP.
Yordano Ventura: Among the hardest-throwing starters in baseball, Ventura took a step forward when he posted a 2.38 ERA across his final 11 regular-season starts in 2015. The right-hander could pitch a gem when he works in front of an elite defensive unit at his pitcher-friendly home park against the Twins.
Jaime Garcia: Garcia -- who posted a 2.43 ERA and a 1.05 WHIP in 2015 -- will be in prime position to silence the opposition when he faces the Braves at offense-suppressing Turner Field. Atlanta's lineup does not feature a single player who hit 20 homers last season.
Francisco Liriano: One of the most dominant southpaws in the Senior Circuit, Liriano has logged a 3.23 ERA and a 9.7 K/9 rate since joining the Pirates at the outset of the 2013 season. Backed by a Pittsburgh club that won 98 games last season, he has the skills to thrive at Great American Ball Park in a seemingly advantageous matchup with Simon.
Jacob deGrom: With a lifetime 2.61 ERA and a 1.05 WHIP, deGrom has needed just two seasons to establish himself as a fantasy ace. The right-hander could post a game-changing total in DraftKings contests when he works at home against a Phillies lineup that includes just one player (Ryan Howard) who reached 15 homers last season.
All statistics are accurate through the completion of Wednesday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB. This story was not subject to the approval of Major League Baseball or its clubs.