Facing reliever Brandon Gomes, the Reds mounted a four-run sixth inning to take a 6-5 lead. Eugenio Suarez hit a two-run double down the left-field line -- tying him for the team lead with five doubles -- and Mesoraco followed with a two-run homer to left-center field for the lead. In his three games since returning from 2015 hip surgery, he is 3-for-6 with two homers.
Reds manager Bryan Price enjoyed getting another solid day from both Mesoraco and Zack Cozart, who was 2-for-3, including an RBI double in the fourth inning. Cozart has been working his way back from left knee surgery in June.
"It's good to see," Price said. "They went down to Minor League camp yesterday and got into the neighborhood of seven or eight at-bats. We're trying to get them up to speed with how many pitches they're seeing and at-bats they're getting. They both came out of the game feeling really good."
Reds starter Alfredo Simon, who signed as a free agent with his former club on Thursday, pitched three perfect innings in his spring debut. Cubs starter Jason Hammel completed five innings with two runs (one earned), three hits, one walk and three strikeouts.
• Welcome back: Simon impressive in return
Hammel said now he just needs to fine-tune some elements of his game.
"I feel pretty crisp, I feel good, I feel like everything I worked on and the things I was focusing on this spring have really started to translate," Hammel said. "My arm felt real good today."
• Hammel, Schwarber battery works well for Cubs
Chicago scored three runs in the fourth inning against lefty reliever Tony Cingrani -- the first runs he's allowed this spring. Two were unearned, but Cingrani did not help himself with back-to-back walks.
Reds Rule 5 pitcher and lefty bullpen candidate Chris O'Grady was pitching in the sixth when Rizzo beat an infield shift by punishing a 1-1 pitch with a homer to right-center field. It's worth noting that Rizzo hit six of his 31 homers off lefties last season.
Up next for the Reds: Following their only off-day of Spring Training on Wednesday, the Reds resume Cactus League play at 4:05 p.m. ET on Thursday vs. the Rangers in Surprise, live on Gameday Audio. Anthony DeSclafani will be the starting pitcher, and he is coming off of an outing vs. Milwaukee in which he gave up four earned runs and six hits over 4 2/3 innings while striking out seven.
Up next for the Cubs: Kyle Hendricks will make his fourth start and fifth appearance this spring when the Cubs travel to Surprise on Wednesday to face the Rangers at 3:05 p.m. CT, and fans can watch live on MLB.TV or listen to an exclusive webcast. The right-hander, expected to be slotted in as the fifth starter, has struck out 14 over 14 innings and given up two earned runs. The Cubs and Rangers will play in the second annual spring Futures Game after the Cactus League game is completed.