The Phillies used a trio of top pitching prospects, as right-hander Zach Eflin, ranked as Philadelphia's No. 13 prospect by MLBPipeline.com, started and gave up one run on four hits over three innings with two strikeouts. The lone run he allowed came in the second on an RBI single from Twins catcher Juan Centeno.
Fellow right-hander Jake Thompson, ranked as the Phillies' No. 2 prospect, also saw action and was impressive, tossing three scoreless frames. He scattered five hits and struck out one.
Righty Mark Appel, ranked as the club's No. 4 prospect, was the last to see action, and he struck out three in two innings. He allowed an unearned run in the seventh, keyed by a throwing error from third baseman Angelys Nina. Twins second baseman Buck Britton plated the run with an RBI groundout.
Milone started for the Twins, surrendering one run on the homer from Rupp in the third. He was otherwise solid, as it was the only hit he gave up in his three innings of work. He struck out three.
"The fastball command was good and I think that's what started it all," Milone said. "And then the changeup. Those were the two pitches that made a difference today."
Designated hitter Byung Ho Park went 2-for-3 for the Twins, a day after he hit his second homer of the spring. First baseman Joe Mauer, wearing sunglasses at the plate for the second time this spring to help with vision problems stemming from his 2013 concussion, went 1-for-2 with a single.
Up next for the Phillies: The Phillies host the Tigers at 1:05 p.m. ET on Thursday at Bright House Field on MLB.TV. Right-hander Aaron Nola is scheduled to make his second Grapefruit League start of the spring. Nola is expected to start Opening Day or the second game of the season, which would put him in line to start the home opener on April 11 against the Padres at Citizens Bank Park.
Up next for the Twins: Right-hander Ervin Santana starts for the Twins, as they travel down the road to JetBlue Park to face the Red Sox at 12:05 p.m. CT on Thursday. It's the second start of the spring for Santana, who allowed two unearned runs in two innings in his debut on Saturday against the Orioles. Jose Berrios, the Twins' No. 2 prospect, will piggyback Santana and is expected to throw roughly 45 pitches.
Rhett Bollinger is a reporter for MLB.com. Read his blog, Bollinger Beat, follow him on Twitter @RhettBollinger and listen to his podcast. This story was not subject to the approval of Major League Baseball or its clubs.