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The catcher was stunned by a foul ball in the sixth inning, and after getting by a pitch in the seventh, he was lifted for a pinch-runner.
"We are all fine. It was actually pretty funny. We were on an Uber ride to this Venezuelan food truck called Sabor Venezolano," Nieves said. "Our driver was driving on a left-only lane and continued straight. The car on our right turned left and hit us."
Five Astros fans driving from Minute Maid Park emerged from the car and were extremely angry, according to Nieves.
"They were barking at our driver and then Salvy gets out of the car," Nieves said. "They are shocked and like, 'Oh my God, it's Salvador Perez!' They asked for pictures and didn't care about the car anymore. We are just happy everybody is OK."
The series is tied at two games apiece. Perez has three hits, including two home runs, in 13 at-bats during the ALDS.
Jesse Sanchez is a national reporter for MLB.com. Follow him on Twitter @JesseSanchezMLB. This story was not subject to the approval of Major League Baseball or its clubs.