Frazier, who was 0-for-1 in the game, then came out before the top of the fourth inning in a double-switch. Ivan De Jesus Jr. moved from second base to third base, while Skip Schumaker played second base and took Frazier's fourth spot in the lineup.
"We felt it would get worse if he stayed out there and continued to play," Reds manager Bryan Price said. "We can't afford to lose any more players right now."
Frazier is batting .257 with a career-high and team-high 35 home runs, and he has recorded 88 RBIs.
Mark Sheldon is a reporter for MLB.com. Read his blog, Mark My Word, follow him on Twitter @m_sheldon and Facebook and listen to his podcast. This story was not subject to the approval of Major League Baseball or its clubs.