Justin Ruggiano (Dodgers): The outfielder will have the opportunity to improve on his lifetime .857 OPS against left-handers (.701 vs. righties) when he faces southpaw Jorge De La Rosa (career 4.57 ERA, 1.43 WHIP). Ruggiano could also excel late in the game against a Rockies relief corps that ranks last in the Majors with a 4.80 ERA.
Scott Van Slyke (Dodgers): Van Slyke owns notable lifetime splits, with an .875 OPS against left-handers in comparison to a .713 mark vs. righties. The outfielder could drive in multiple runs at the expense of De La Rosa (4.28 ERA, 1.38 WHIP in 2015). Also of note: Van Slyke and his teammates will attempt to put balls into play against a Rockies squad that ranks 29th in baseball with a .672 defensive efficiency ratio.
Nolan Arenado (Rockies): With 38 homers across 458 at-bats, the third baseman has been one of the most powerful hitters in baseball this season. Arenado could drive in multiple runs when he brings his balanced lifetime splits into a matchup with Dodgers southpaw Alex Wood (1.44 WHIP in 2015).
Matt Duffy (Giants): The third baseman will be poised to improve on his season-to-date .301 batting average when he puts his career .785 OPS against right-handers (.687 vs. lefties) to the test against Reds rookie righty Michael Lorenzen (5.45 ERA, 1.68 WHIP).
David Ortiz (Red Sox): With 34 homers and 95 RBIs across 476 at-bats this season, Ortiz continues to be one of the most effective power hitters in baseball. The slugger could drive in multiple runs when he brings his impressive career .975 OPS against right-handers (.814 vs. lefties) into hitter-friendly Camden Yards against rookie righty Mike Wright (5.45 ERA, 1.41 WHIP).
David Wright (Mets): With a lifetime .341/.433/.573 slash line against left-handers, the third baseman has proven to be among the best in baseball during those matchups. Wright could drive in multiple runs when he faces Marlins rookie southpaw Adam Conley (4.93 ERA, 1.55 WHIP).
Nolan Reimold (Orioles): This season, the outfielder has produced an .870 OPS against left-handers that exceeds his .675 mark vs. righties. Reimold -- who is hitting .345 with three homers across 29 at-bats since Sept. 6 -- could thrive when he bats at his hitter-friendly home park against rookie southpaw Henry Owens (5.25 ERA, 1.47 WHIP) and a Red Sox bullpen that ranks 26th in baseball with a 4.33 ERA.
Jason Heyward (Cardinals): Hitting .292 with 11 homers and 21 steals across 542 plate appearances this season, the outfielder possesses the diverse skill set that DraftKings owners covet. Heyward could contribute in multiple ways when he bats at hitter-friendly Miller Park against righty Wily Peralta (4.14 ERA, 1.47 WHIP in 2015).
Matt Carpenter (Cardinals): The third baseman has long fared best vs. right-handers, against whom he has posted a lifetime .838 OPS (.759 vs. lefties). From his premium lineup, Carpenter could have a terrific game against Peralta (career 4.17 FIP, 1.37 WHIP).
David Peralta (D-backs): The outfielder -- who has hit .375 since Aug. 9 -- has produced pronounced career splits, with an .883 OPS against right-handers in comparison to a .616 mark vs. lefties. Peralta could drive in multiple runs when he hits at his offense-inducing home park against Padres righty Andrew Cashner (4.27 ERA, 1.43 WHIP in 2015).
Jayson Werth (Nationals): The outfielder -- who is hitting .307 since Aug. 27 -- could thrive when he brings his lifetime .928 OPS against left-handers (.795 vs. righties) into a matchup with rookie southpaw Adam Morgan (4.60 ERA) at hitter-friendly Citizens Bank Park. Also of note: Werth and his teammates will attempt to put balls into play against a Phillies squad that ranks last in the Majors with a .666 defensive efficiency ratio.
Mark Canha (A's): The rookie first baseman has produced pronounced splits, with an .837 OPS against right-handers that exceeds his .546 mark vs. lefties. Canha could display his power when he bats at offense-inducing U.S. Cellular Field against White Sox righty Erik Johnson (career 4.48 ERA, 1.59 WHIP).
Josh Reddick (A's): The outfielder will be set to display his power when he faces Johnson (career 5.40 FIP) at Chicago's hitter-friendly venue. As a big leaguer, Reddick has posted a .770 OPS against right-handers in comparison to a .688 mark vs. lefties. Also of note: Reddick and his teammates will attempt to put balls into play against a White Sox squad that ranks 28th in the Majors with a .674 defensive efficiency ratio.
Jake Arrieta (Cubs): With a 0.93 ERA since the All-Star break, the right-hander has been arguably the best pitcher in baseball during the second half. The right-hander could post a difference-making total in DraftKings contests when he faces the Pirates at pitcher-friendly PNC Park.
Bartolo Colon (Mets):
With a 0.57 ERA since Aug. 26, the right-hander is one of the hottest starters in the Senior Circuit. Colon could continue to silence the opposition when he works at home against a Marlins squad that ranks last in the Majors with a .667 OPS vs. righties.
Jaime Garcia (Cardinals):
With a 2.33 ERA and a 1.01 WHIP on the year, the left-hander has been a cost-effective starter in many DraftKings contests. Garcia could continue his outstanding campaign when he faces a Brewers lineup that ranks 24th in the Majors with a .687 OPS against southpaws. Once he leaves the game, Garcia could see his quest for a win aided by a Cardinals bullpen that leads the Majors with a 2.56 ERA.
Luis Severino (Yankees): With a 3.35 ERA across seven starts, the rookie righty has already become a trusted starter in DraftKings contests. Severino could deliver a stellar outing when he works at pitcher-friendly Tropicana Field against a Rays lineup that ranks 26th in baseball with a .694 OPS against righties.
All statistics are accurate through the completion of Monday's games.