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The players listed below could provide difference-making stats for DraftKings participants on Monday.
Miguel Cabrera (Tigers): The first baseman -- who leads the Majors with a .346 batting average this season -- will be primed to improve on his impressive career .323/.390/.564 slash line against right-handers when he faces righty Tyler Duffey (4.18 ERA, 1.45 WHIP). Cabrera could also thrive late in the game against a Twins bullpen that sits 22nd in the Majors with a 4.08 ERA.
Anthony Gose (Tigers): The outfielder may reach base often when he brings his career .697 OPS against right-handers (.492 vs. lefties) into a matchup with Duffey (.308 average allowed to left-handed batters) and a suspect Twins relief corps. Gose could also swipe his 21st base of the season at the expense of Kurt Suzuki, who has allowed more steals than all but three catchers in 2015.
David Ortiz (Red Sox): With 34 homers and 95 RBIs across 473 at-bats this season, Ortiz continues to be one of the most effective power hitters in baseball. The slugger will be set to drive in multiple runs when he brings his career .975 OPS against right-handers (.815 vs. lefties) into hitter-friendly Camden Yards to face righty Kevin Gausman (career 4.28 ERA, 1.30 WHIP).
Brandon Guyer (Rays): The outfielder owns notable career splits, with a .778 OPS against left-handers in comparison to a .671 mark vs. righties. Hitting out of the leadoff spot, Guyer may reach base often or score multiple runs when he faces Yankees southpaw CC Sabathia (4.97 ERA since the outset of 2013).
Evan Longoria (Rays): As the centerpiece of the Rays lineup, the third baseman will bring an impressive career .926 OPS against left-handers (.803 vs. righties) into a matchup with Sabathia (5.16 ERA, 1.45 WHIP in 2015). Since Aug. 26, Longoria has hit .322 with six homers across 59 at-bats.
Logan Forsythe (Rays): Hitting .287 with 16 homers and nine steals across 558 plate appearances, the second baseman is coming down the stretch of a breakout season. Forsythe could excel when he puts his lifetime .833 OPS against left-handers (.635 vs. righties) to the test against Sabathia (4.80 FIP in 2015).
Brian Dozier (Twins): With 27 homers across 549 at-bats, the second baseman has been the most powerful player at his premium position this season. Dozier could put a ball into the outfield seats when he takes his lifetime .839 OPS against left-handers (.692 vs. righties) into a matchup with Tigers southpaw Kyle Lobstein (career 4.92 ERA, 1.41 WHIP).
Trevor Plouffe (Twins): The third baseman has produced a lifetime .810 OPS against left-handers that exceeds his .700 mark vs. righties. Plouffe could drive in multiple runs when he faces Lobstein (career 4.26 FIP) and a Tigers bullpen that sits 28th in the Majors with a 4.75 ERA.
David Wright (Mets): With a lofty lifetime .341/.434/.573 slash line against left-handers, the third baseman has proven to be among the best in baseball during those matchups. Wright could drive in multiple runs when he tangles with Marlins rookie southpaw Justin Nicolino (1.34 WHIP).
Wilmer Flores (Mets): This season, the shortstop has produced a .988 OPS against left-handers that exceeds his .646 mark vs. righties. Flores could succeed when facing the inexperienced Nicolino, who has registered a 4.55 FIP across his initial eight starts.
David Peralta (D-backs): The outfielder -- who has hit .369 since Aug. 9 -- will be in position to rip a round-tripper when he bats at his hitter-friendly home park against Padres righty James Shields (1.4 HR/9 rate in 2015). In his career, Peralta has registered an .883 OPS against right-handers that exceeds his .616 mark vs. lefties.
Adrian Gonzalez (Dodgers): The first baseman will be set to improve on his impressive career .299/.375/.529 slash line against right-handers when he faces rookie righty Jon Gray (5.17 ERA, 1.53 WHIP). Gonzalez may also thrive late in the game against a Rockies relief corps that ranks last in the Majors with a 4.84 ERA.
Andre Ethier (Dodgers): The outfielder has traditionally excelled vs. right-handers such as Gray, against whom Ethier has posted a lifetime .889 OPS (.636 vs. lefties). Also of note: Ethier and his teammates will attempt to put balls into play against a Rockies squad that ranks 29th in the Majors with a .672 defensive efficiency ratio.
Joey Votto (Reds): Votto has used a patient, powerful approach to build a lofty lifetime .318/.435/.550 slash line against right-handers. The first baseman -- who has posted a .566 on-base percentage since the All-Star break -- could reach base often when he faces Giants righty Tim Hudson (4.51 ERA, 1.36 WHIP in 2015).
Jordan Zimmermann (Nationals): The right-hander will be primed to improve on his career 3.25 ERA and 1.16 WHIP when he faces a Phillies lineup that ranks 28th in the Majors with a .685 OPS against righties.
Sonny Gray (A's): With a season-to-date 2.28 ERA and a 1.00 WHIP, the right-hander has been among the most dominant starters in the Junior Circuit. Gray will be primed to continue his outstanding campaign when he faces a White Sox team that ranks 24th in the Majors with a .702 OPS against righties. He could also come away with a win in a seemingly advantageous matchup with John Danks (4.60 ERA in 2015).
Clayton Kershaw (Dodgers): Arguably the best pitcher in baseball, Kershaw has posted a 1.91 ERA since the outset of the 2013 season and an 11.6 K/9 rate during the current campaign. The left-hander could deliver a stellar outing when he works at his pitcher-friendly home park against a Rockies lineup that ranks 26th in the Majors with a .670 OPS against southpaws and sits 29th in baseball with a .665 OPS on the road.
All statistics are accurate through the completion of Saturday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB. This story was not subject to the approval of Major League Baseball or its clubs.