Several of Ortiz's past and present teammates took to the web in celebration of the historic feat.
It wasn't just teammates, however. Current and former players all across the league chimed in with support of the 39-year-old veteran.
Even a few pitchers who contributed to Ortiz's home run count -- including Craig Breslow, now pitching for the Red Sox, and Phil Hughes -- got in on the fun. Breslow surrendered No. 303 in 2009, while Hughes gave up No. 324 and 377 in '09 and 2011.
Other figures throughout Boston also cheered on Big Papi, including the New England Patriots and the city's mayor, Marty Walsh. As did fellow Dominican Al Horford of the Atlanta Hawks and college basketball broadcaster Dick Vitale.
Chad Thornburg is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.