Alex Gordon (Royals): The outfielder will be in position to improve on his lifetime .803 OPS against right-handers (.752 vs. lefties) when he vacates his pitcher-friendly home park and faces Orioles righty Chris Tillman (career 4.20 ERA, 1.31 WHIP) at offense-inducing Camden Yards.
Eric Hosmer (Royals): From the cleanup spot, the first baseman may drive in multiple runs when he brings his lifetime .805 OPS against right-handers (.682 vs. lefties) into a matchup with Tillman (5.15 ERA, 1.40 WHIP in 2015) at Baltimore's offense-inducing venue.
Kendys Morales (Royals): The slugger has long fared best vs. right-handers, against whom he has posted a lifetime .819 OPS (.727 vs. lefties). Morales -- who ranks third in the American League with 101 RBIs this season -- could drive in multiple runs when he faces Tillman (career 4.52 FIP).
Jason Heyward (Cardinals): Hitting .287 with 11 homers and 21 steals across 529 plate appearances this season, the outfielder possesses the diverse skill set that DraftKings owners covet. Heyward has the plate skills to thrive when he brings his lifetime .835 OPS against right-handers (.658 vs. lefties) into a matchup with righty Anthony DeSclafani (career 4.18 ERA, 1.34 WHIP) at hitter-friendly Great American Ball Park. He also has the speed to swipe a bag against catcher Brayan Pena, who has thwarted 12 of 67 would-be basestealers this season.
Matt Carpenter (Cardinals): From his premium lineup position, the third baseman will be primed to excel when he puts his lifetime .838 OPS against right-handers (.763 vs. lefties) to the test against DeSclafani (1.33 WHIP in 2015) at Cincinnati's hitter-friendly venue.
Anthony Rizzo (Cubs): Hitting .285 with 28 homers and 15 steals across 597 plate appearances, the first baseman has contributed to DraftKings squads in multiple ways this season. Rizzo could rip a round-tripper when he faces Phillies rookie righty Jerad Eickhoff (4.70 ERA, 1.26 WHIP) at homer-happy Citizens Bank Park. He may also swipe a base against catcher Carlos Ruiz, who has thwarted 10 of 54 would-be basestealers this season.
Kris Bryant (Cubs): With 23 homers, 12 steals and a .365 on-base percentage across 550 plate appearances, the rookie third baseman already ranks among the top offensive players at his position. Bryant could drive in multiple runs when he faces Eickhoff or swipe a bag at the expense of Ruiz.
Miguel Montero (Cubs): The catcher has produced pronounced career splits, with a .793 OPS against right-handers that exceeds his .660 mark vs. lefties. Montero could be part of a Cubs stack -- along with Rizzo, Bryant, outfielder Chris Coghlan and catcher Kyle Schwarber -- against Eickhoff. Also of note: Montero and his teammates will attempt to put balls into play against a Phillies squad that ranks last in the Majors with a .666 defensive efficiency ratio.
Jackie Bradley Jr. (Red Sox): Hitting .416 with seven homers and 32 RBIs across 89 at-bats since Aug. 9, the outfielder has been a major factor in many recent DraftKings lineups. Bradley could stay hot when he puts his lifetime .741 OPS against left-handers (.606 vs. righties) on the line against Rays southpaw Matt Moore (career 4.05 FIP, 1.38 WHIP).
Xander Bogaerts (Red Sox): The shortstop owns notable career splits, with an .836 OPS against left-handers in comparison to a .659 mark vs. righties. Bogaerts could reach base often when he faces Moore, who has posted an 8.04 ERA and a 1.91 WHIP across seven starts since returning from Tommy John surgery earlier this summer.
Lucas Duda (Mets): Since the outset of the 2014 season, the first baseman has used a patient, powerful approach to post a .253/.360/.500 slash line against right-handers. Duda will be in position to drive in multiple runs when he faces rookie righty Williams Perez (5.42 ERA, 1.57 WHIP) and a Braves bullpen that ranks 29th in the Majors with a 4.74 ERA.
Curtis Granderson (Mets): With 23 homers, 11 steals and 83 runs across 603 plate appearances, Granderson has been a cost-effective outfielder in many 2015 DraftKings squads. From his perch atop the lineup, he may maximize his opportunities to succeed against Perez (5.11 FIP) and a suspect Braves relief corps. Also of note: Granderson and his teammates will attempt to put balls into play against an Atlanta squad that ranks 26th in baseball with a .678 defensive efficiency ratio.
Adrian Beltre (Rangers): With a lofty lifetime .289/.361/.484 slash line against left-handers, Beltre has proven to wield a potent bat in those matchups. The third baseman could have a terrific game when he bats at his hitter-friendly home park against A's southpaw Sean Nolin, who has produced a 10.80 ERA and a 2.04 WHIP across 8 1/3 Major League innings.
Jeff Locke (Pirates): With a season-to-date 4.56 ERA and a 1.43 WHIP, the left-hander may be an economical second starter for DraftKings participants when he works at his pitcher-friendly home park against a Brewers lineup that ranks 25th in baseball with a .685 OPS against southpaws. Once he leaves the game, Locke could see his quest for a win aided by a Pirates relief corps that sits third in the Majors with a 2.72 ERA.
Noah Syndergaard (Mets): The rookie righty (3.31 ERA) has the skills to spin a gem when he works at pitcher-friendly Turner Field against a Braves lineup that ranks 28th in the Majors with a .685 OPS against right-handers and last in baseball with 86 homers.
Madison Bumgarner (Giants): The left-hander is the model of a consistent ace, having posted an ERA between 2.77 and 3.37 across each season since 2010. Bumgarner will be primed to deliver a stellar outing when he works at his pitcher-friendly home park against a Padres lineup that ranks 24th in the Majors with a .686 OPS against southpaws and fourth overall with 1,154 strikeouts.
Roenis Elias (Mariners): With a career 4.02 ERA and a 1.30 WHIP, the left-hander may be a cost-effective second starter for DraftKings participants when he works at his pitcher-friendly home park against the Rockies. Colorado ranks 26th in the Majors with a .678 OPS against southpaws and 28th with a .668 OPS on the road.
All statistics are accurate through the completion of Thursday's games.