The Interleague Play schedule is with the National League West, and the O's will travel to the West Coast for a visit to the Padres (June 28-29), Giants (Aug. 12-14) and Dodgers (July 4-6), as well as their yearly Beltway Series with the Nationals (Aug. 24-25).
• Tentative 2016 Orioles schedule
Baltimore will host the Padres (June 21-22), Rockies (July 25-27), Nationals (Aug. 22-23) and D-backs (Sept. 23-25) to complete Interleague Play.
The Orioles will again host each American League East opponent for three series throughout the season. The Red Sox will play a total of 10 games in Baltimore: May 30-June 2, Aug. 16-17 and Sept. 19-22. The Rays will be at Camden Yards on April 8-10, June 24-26 and Sept. 15-18. The Yankees will come to town May 3-5, June 3-5 and Sept. 2-4, while the Blue Jays will travel to Baltimore April 19-21, June 17-19 and Aug. 29-31.
The Orioles' home schedule also includes games on Mother's Day (May 8 vs. Oakland), Memorial Day (May 30 vs. Boston) and Father's Day (June 19 vs. Toronto).
May and June are the busiest months at Camden Yards, with 16 home game in each. The Orioles will play a pair of 10-game homestands: April 28-May 8 (White Sox, Yankees and A's) and May 30-June 8 (Red Sox, Yankees and Royals) before finishing the home portion of their schedule with an 11-game homestand from Sept. 15-25 (Rays, Red Sox and D-backs).
Sixteen of the O's 25 games in July will be on the road. The O's have a 10-game road trip from Aug. 5-14 (White Sox, Athletics and Giants), and three nine-game road trips: May 20-29 (Angels, Astros and Indians), June 28-July 6 (Padres, Mariners and Dodgers) and Sept. 5-14 (Rays, Tigers and Red Sox).
They will wrap up their regular season with a six-game road trip against the Blue Jays (Sept. 27-29) and Yankees (Sept. 30-Oct. 2).
Brittany Ghiroli is a reporter for MLB.com. Read her blog, Britt's Bird Watch, follow her on Facebook and Twitter @britt_ghiroli, and listen to her podcast. This story was not subject to the approval of Major League Baseball or its clubs.