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The players listed below could provide difference-making stats for DraftKings participants on Monday.
David Ortiz (Red Sox): The slugger could rip a round-tripper or drive in multiple runs when he brings his impressive career .293/.397/.576 slash line against right-handers into a matchup with Yankees righty Ivan Nova (lifetime 4.23 ERA, 1.39 WHIP). After a slow start to the season, Ortiz has hit .302 with 21 homers and 56 RBIs since June 11.
Evan Longoria (Rays): The third baseman has long fared best vs. left-handers, against whom he has registered a lifetime .921 OPS (.799 vs. righties). Longoria could excel when he vacates his pitcher-friendly home park and travels to offense-inducing Camden Yards to meet up with Orioles southpaw Wei-Yin Chen (4.25 FIP in 2015).
Logan Forsythe (Rays): Hitting .275 with 15 homers and nine steals across 507 plate appearances, the second baseman has been a cost-effective option at a premium position in many 2015 DraftKings contests. Forsythe will be primed to produce when he puts his lifetime .815 OPS against left-handers (.624 vs. righties) on the line vs. Chen at Baltimore's hitter-friendly venue.
Yoenis Cespedes (Mets): Cespedes is on a roll -- he has hit .297 with eight homers and 18 RBIs in his past 16 games -- and he could continue to get the job done at the plate when he faces Phillies right-hander Jerad Eickhoff on Monday. Eickhoff will be making his third Major League start after posting a career 4.14 ERA in the Minors. Cespedes owns an .805 OPS vs. righties (.771 against lefties) during his big league tenure.
Curtis Granderson (Mets): With a lifetime .862 OPS vs. right-handed pitchers (.691 vs. lefties), Granderson could have considerable success Monday against the inexperienced Eickhoff. Notably, the outfielder has notched a .929 OPS since the All-Star break this season.
Alex Rodriguez (Yankees): Rodriguez has been a factor in many DraftKings contests this season, as he has produced 26 homers with 69 RBIs. Possessing balanced career splits that include a .941 OPS vs. lefties, Rodriguez could be a driving force for the Yankees' offense against Red Sox southpaw Eduardo Rodriguez.
Jhonny Peralta (Cardinals): With 16 homers and 58 RBIs across 485 at-bats, the shortstop has been among the most productive players at his premium position this season. Peralta could thrive when he brings his lifetime .796 OPS against left-handers (.743 vs. righties) into a matchup with Nationals southpaw Gio Gonzalez (4.11 ERA, 1.48 WHIP in 2015).
Stephen Piscotty (Cardinals): Hitting .344 across 125 at-bats since joining the Cardinals on July 21, the rookie outfielder has been a cost-effective option in many recent DraftKings contests. Piscotty may drive in multiple runs when he brings his 1.006 OPS against left-handers (.935 vs. righties) into a matchup with Gonzalez.
Paul Goldschmidt (D-backs): Goldschmidt does his best work against left-handers, but he also owns an impressive lifetime .289/.384/.509 slash line against righties. The first baseman -- who is hitting .326 with 26 homers and 20 steals across 567 plate appearances this season -- could be worth a major expenditure in DraftKings contests when he travels to homer-happy Coors Field to face righty Chad Bettis (career 5.70 ERA, 1.60 WHIP).
David Peralta (D-backs): Hitting .359 with five homers and 29 RBIs across 131 at-bats since the All-Star break, Peralta has been a major factor in many recent DraftKings contests. The outfielder will be poised to produce when he brings his lifetime .878 OPS against right-handers (.607 vs. lefties) into a matchup with Bettis (4.69 ERA, 1.40 WHIP in 2015) and a Rockies bullpen that sits last in baseball with a 4.91 ERA.
Nolan Arenado (Rockies): In his career, the third baseman has fared best when facing left-handers (.287/.350/.493 slash line) and when working at his hitter-friendly home park (.300/.338/.534 slash line). Arenado could have a major impact in DraftKings contests when he hits at home against D-backs southpaw Robbie Ray (career 4.89 ERA).
David Price (Blue Jays): With a season-to-date 2.42 ERA and a 1.08 WHIP, the left-hander continues to be one of the most dominant pitchers in baseball. Price has the skills to post a difference-making total in DraftKings contests when he faces the Indians on Monday.
Colby Lewis (Rangers): DraftKings participants who look beyond Lewis' career 4.77 ERA could find an economical second starter on Monday when the Rangers face the Padres at pitcher-friendly Petco Park. San Diego's lineup -- which ranks 27th in baseball with a .683 OPS vs. righties -- includes several right-handed sluggers. In his career, Lewis has handled righty batters to the tune of a .726 OPS (.817 OPS allowed to lefty hitters).
Hector Santiago (Angels): With a 3.13 ERA and 138 strikeouts in 149 2/3 innings this season, the left-hander has been a productive starter in many 2015 DraftKings contests. Santiago could compile quality frames when he visits pitcher-friendly O.co Coliseum to face an A's lineup that sits 22nd in the Majors with a .688 OPS vs. southpaws.
All statistics are accurate through the completion of Saturday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB. This story was not subject to the approval of Major League Baseball or its clubs.