Uggla's two-run homer off David Herndon in the eighth inning placed him in the history books. The slugger is the first second baseman in Major League history to post four 30-homer seasons, and they've all come consecutively.
The blast came on an otherwise forgettable night as the Marlins lost, 11-4, to the Phillies in front of 20,616 at Sun Life Stadium.
"It was a bad game, but you still have to play and the numbers still count," Uggla said. "That's not what you're trying to do. Obviously, we were trying to come back and win. We just kind of ran out of innings. It just so happened that that home run fell on this game. It's over with and done with, and I can enjoy it a little bit.
"I'll really enjoy it at the end of the season. Again, who would have thought?"
Uggla also is the only Marlins player to post four 30-homer seasons, and he's done it in four consecutive seasons. Miguel Cabrera had three years where he reached the benchmark.
Since breaking in as a rookie in 2006, Uggla has been a steady run producer. He now has 92 RBIs, which matches his career best first set in '08. After belting 27 homers as a rookie, Uggla has reached 30 in four straight years. His season best is 32, also in '08.
Before his long fly ball to left field on Monday, Uggla had gone 12 straight games without a blast since he homered on Aug. 27 at Atlanta. Admittedly, he was thinking about the milestone.
"It was wearing on me a little bit," said Uggla, who also is the franchise record holder with 151 homers. "You're one away from that. Your body and your mind tend to take over, and you try to do too much. That's what I've been doing the last week and a half, trying to make it happen rather than letting it happen."
In exchange for an autographed baseball and a signed bat, a fan traded the historic home run ball back to Uggla, who plans on giving the ball to his kids.
Along with Uggla's dinger, rookie Logan Morrison also homered for Florida.
But the night belonged to the Phillies.
Changing scenery didn't reverse Andrew Miller's fortunes against the Philadelphia. The left-hander surrendered three homers and seven runs over five innings.
Sensational second sackers
"They have a good lineup, but ultimately, I didn't make enough good pitches," Miller said. "I felt good. It was kind of a similar story to the other night. I felt like they certainly didn't miss any mistakes. They're a good-hitting team. I made far too many [mistakes]."
A couple of errors meant two of the runs Miller gave up on Monday were unearned.
The damage the Phillies did early was enough to snap the Marlins' three-game winning streak.
Morrison's second home run of the season was the only run the Marlins produced off Joe Blanton (7-6), who struck out eight in six innings.
Morrison has now reached base either by a hit, walk or hit-by-pitch in 33 straight games, which is three shy of Hanley Ramirez's franchise rookie record set in 2006.
"It was a tough game, but it was a good thing to see those young kids out there getting better and better," manager Edwin Rodriguez said.
The way the Marlins competed after falling behind by 10 runs was a source of pride for the team, which features three impressive rookies. Mike Stanton doubled hard to deep center in Florida's three-run eighth inning. Gaby Sanchez added a single.
The liner off Stanton's bat certainly impressed Phillies manager Charlie Manuel.
"They've got some guys who can hit," Manuel said. "You don't hit the ball harder than Stanton hit that ball. If he hits it any harder, he might knock the fences down. You know what was good about that? I got to see it."
The Phillies certainly showed plenty of firepower as they beat Florida for the fourth straight time dating back to their four-game series last week in Philadelphia.
Jayson Werth, Chase Utley and Carlos Ruiz each homered off Miller, who allowed nine hits and walked three while striking out five.
Greg Dobbs added a pinch-hit homer off Jose Ceda in the seventh inning.
With the loss, the Marlins' record falls to 73-70, and they are 10 back of the Phillies in the National League East.
The Phillies struck quickly off Miller, and they didn't look back.
Werth has had his struggles against the Marlins all season. Entering Monday, he was batting .180 in 50 at-bats. But with one out in the second inning, Werth delivered an opposite-field home run to put the Phillies on the board.
In the third inning, Utley connected with two outs for his 14th of the season.
The lead ballooned to four runs in the fourth on Ruiz's two-run shot to left.
"It was a tough night for Miller and the whole team," Rodriguez said. "We struggled getting people out, but Miller gave us a good effort. He gave 100 percent. But we're facing a very good-hitting team. We came back.
"You have to enjoy Danny Uggla's 30th home run and those kids, Michael Stanton diving for balls and all that. Tough loss, but then again, those guys -- they're learning."
Joe Frisaro is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.