It will mark Doubront's third start in an A's uniform, after he began his tenure in Oakland pitching out of the bullpen. He allowed one unearned run in six innings against the Dodgers on Aug. 18, and made it through two scoreless frames against the Mariners on Monday before departing for X-rays on his foot that proved negative.
Doubront has faced the D-backs just once in his career, a seven-inning scoreless outing in 2013 as a member of the Red Sox.
A's ace Sonny Gray will pitch Friday's opener, and right-hander Jesse Chavez will close out the Interleague series with a start in Sunday's matinee.
Jane Lee is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.