Brian Dozier (Twins): With 25 homers across 463 at-bats, the second baseman has been the most powerful player at his position this season. From his perch atop the lineup, Dozier could maximize his opportunities to contribute when he brings his career .849 OPS against left-handers (.694 vs. righties) into a matchup with Orioles southpaw Wei-Yin Chen (4.37 FIP in 2015).
Trevor Plouffe (Twins): As a big leaguer, Plouffe has handled left-handers to the tune of an .821 OPS (.697 vs. righties). The third baseman could excel at hitter-friendly Camden Yards against Chen, who in his career has allowed right-handed hitters such as Plouffe to post a .761 OPS (.676 OPS allowed to lefty batters).
Buster Posey (Giants): With a lifetime .327/.384/.561 line against left-handers, Posey has proven to wield a potent bat in those matchups. The catcher could provide elite production at a premium position when he bats out of the third spot in the lineup against Pirates southpaw Jeff Locke (career 4.09 ERA, 1.37 WHIP).
Joey Votto (Reds): The first baseman has used a patient, powerful approach to build an impressive lifetime .316/.430/.547 slash line against right-handers. Votto could excel at his hitter-friendly home park when he meets up with D-backs righty Rubby De La Rosa (career 4.37 ERA, 1.39 WHIP).
Jay Bruce (Reds): In his career, Bruce has posted an .816 OPS against right-handers that exceeds his .722 mark vs. lefties. The outfielder -- who has hit 132 homers since the outset of the 2011 season -- could display his power when he bats at his offense-inducing home park against De La Rosa (4.40 ERA, 1.31 WHIP in 2015).
Jose Altuve (Astros): With a career .352/.395/.487 line against left-handers, Altuve has proven to be among the best in baseball during those matchups. From his perch atop the lineup, the second baseman could reach base often or score multiple runs when he faces Dodgers southpaw Brett Anderson (1.33 WHIP in 2015).
Carlos Correa (Astros): With 15 homers and 10 steals across 270 plate appearances, the rookie shortstop has been a notable factor in many recent DraftKings contests. Correa could excel when he brings his .976 OPS against left-handers (.859 vs. righties) into a matchup with Anderson (career 1.29 WHIP).
Lorenzo Cain (Royals): With 12 homers and 24 steals across 450 plate appearances this season, Cain possesses the diverse skill set that DraftKings participants covet. The outfielder could contribute in multiple ways when he brings his career .814 OPS against right-handers (.726 vs. lefties) into a matchup with Red Sox rookie southpaw Henry Owens, who has posted a 6.19 ERA and a 1.50 WHIP across 16 innings.
Lucas Duda (Mets): Since the outset of last season, the first baseman has combined patience with power to build a .253/.360/.503 slash line against right-handers. Duda could rip his 22nd round-tripper of the season when he visits homer-happy Coors Field to face rookie righty Jon Gray, who will be making his fourth Major League start.
Curtis Granderson (Mets): With 22 homers, 66 runs and nine steals across 514 plate appearances, the outfielder has contributed to DraftKings squads in multiple ways this season. From his perch atop the lineup, Granderson could thrive when he brings his lifetime .861 OPS against right-handers (.688 vs. lefties) into a matchup with Gray and a Rockies bullpen that ranks last in baseball with a 5.03 ERA. Also of note: Granderson and his teammates will attempt to put balls into play against a Rockies squad that sits 29th in the Majors with a .673 defensive efficiency ratio.
Charlie Blackmon (Rockies): In his career, the outfielder has fared best when facing right-handers (.295/.344/.452 slash line) and when batting at his hitter-friendly home park (.333/.384/.493 line). Blackmon -- who has compiled 13 homers and 31 steals across 506 plate appearances this season -- could be worth a major investment in DraftKings contests when he hits at home against Mets righty Bartolo Colon (4.58 ERA in 2015).
Nick Hundley (Rockies): The catcher -- who has posted a .343/.374/.552 slash line at Coors Field this season -- owns a career .726 OPS against right-handers that exceeds his .606 mark vs. lefties. Hundley could drive in multiple runs when he bats at his offense-inducing home park against Colon (career 1.31 WHIP).
Dee Gordon (Marlins): The second baseman will bring his career .701 OPS against right-handers (.656 vs. lefties) into a matchup with Phillies righty Jerad Eickhoff, who will be making his Major League debut. Gordon could reach base often against the inexperienced Eickhoff and swipe his 41st bag of the season against catcher Carlos Ruiz, who has thwarted just 10 of 51 would-be basestealers in 2015.
Gio Gonzalez (Nationals): With a 3.86 ERA and a 1.44 WHIP this year, the left-hander could have an economical price tag in DraftKings contests when he works at his pitcher-friendly home park against a Brewers squad that ranks 28th in the Majors with a .647 OPS vs. southpaws.
Madison Bumgarner (Giants): The left-hander is one of the most consistent aces in baseball, having posted an ERA between 2.77 and 3.37 in each season since 2010. Bumgarner -- who fanned 14 batters during a shutout in his most recent start -- could thrive in an outing against the Pirates at pitcher-friendly PNC Park.
Chris Bassitt (A's): With a 2.44 ERA and a 0.95 WHIP across eight starts since joining the A's rotation, Bassitt has been a cost-effective option in many recent DraftKings contests. The right-hander could continue his recent run of success when he works at his pitcher-friendly home park against a Rays lineup that ranks 28th in baseball with a .679 OPS against righties.
John Lackey (Cardinals): With a season-to-date 2.87 ERA and a 1.18 WHIP, Lackey has been a stable source of production in many 2015 DraftKings contests. The right-hander could compile quality frames when he plies his trade at pitcher-friendly Petco Park against a Padres lineup that ranks 26th in the Majors with a .684 OPS against righties.
All statistics are accurate through the completion of Wednesday's games.
This story was not subject to the approval of Major League Baseball or its clubs.