David Ortiz (Red Sox): The slugger will be in position to improve on his lofty lifetime .292/.396/.575 slash line against right-handers when he hits at home against Indians righty Trevor Bauer (career 4.40 ERA, 1.37 WHIP). After a slow start to the season, Ortiz has rediscovered his power stroke by collecting 16 homers and 44 RBIs across 166 at-bats since June 21.
Brian McCann (Yankees): The catcher will be poised to deliver production from a premium position when he puts his lifetime .828 OPS against right-handers (.754 vs. lefties) to the test against righty Mike Pelfrey (career 4.46 ERA, 1.47 WHIP). McCann could also excel late in the game at his hitter-friendly home park against a Twins bullpen that ranks 22nd in the Majors with a 4.08 ERA.
Matt Carpenter (Cardinals): From his premium lineup spot, the third baseman will maximize his opportunities to collect hits and runs when he brings his lifetime .839 OPS against right-handers (.773 vs. lefties) into a matchup with Giants righty Ryan Vogelsong (career 4.39 ERA, 1.39 WHIP).
Albert Pujols (Angels): With a career .317/.407/.603 line against left-handers, the first baseman has proven to wield a potent bat in such matchups. Pujols could drive in multiple runs when he faces White Sox southpaw John Danks (4.58 ERA, 1.42 WHIP in 2015).
Mike Trout (Angels): Hitting .298 with 33 homers in 423 at-bats this season, the outfielder could be worth a major investment in DraftKings contests when he puts his career .285/.391/.524 slash line against left-handers on the line vs. Danks. Also of note: Trout and his teammates will attempt to put balls into play against a White Sox squad that ranks 29th in baseball with a .670 defensive efficiency ratio.
Ryan Braun (Brewers): With a lifetime .334/.401/.628 slash line against left-handers, Braun has proven to be among the best in baseball during those matchups. The outfielder could drive in multiple runs when he bats at his hitter-friendly home park against Marlins rookie southpaw Adam Conley, who has thrown 18 Major League innings.
Jonathan Lucroy (Brewers): The catcher has registered notable career splits, with an .845 OPS against left-handers in comparison to a .739 mark vs. righties. Batting .239 this season, Lucroy could be a cost-effective option at a premium position in DraftKings contests when he hits at home against Conley (5.00 ERA).
Bryce Harper (Nationals): Batting .328 with 30 homers and 73 RBIs across 378 at-bats, the outfielder has been among the best hitters in baseball this season. Harper will be set to improve on his lifetime .932 OPS against right-handers (.762 vs. lefties) when he faces righty David Hale (5.69 ERA, 1.39 WHIP in 2015) at homer-happy Coors Field. Also of note: Harper and his teammates will attempt to put balls into play against a Rockies squad that ranks 28th in baseball with a .674 defensive efficiency ratio.
Robinson Cano (Mariners): Hitting .342 with nine homers across 158 at-bats since July 1, the second baseman has recovered from a slow start to the season. Cano could provide production at a premium position when he brings his lofty lifetime .317/.364/.523 slash line against right-handers into hitter-friendly Globe Life Park in Arlington to face rookie righty Chi Chi Gonzalez (4.22 ERA, 1.31 WHIP in 2015).
Seth Smith (Mariners): The outfielder will be primed to improve on his lifetime .831 OPS against right-handers (.612 vs. lefties) when he meets the inexperienced Gonzalez (4.98 FIP this season). Smith may also thrive late in the game against a Rangers relief corps that ranks 29th in the Majors with a 4.55 ERA.
Kyle Seager (Mariners): The third baseman has long fared best vs. right-handers, against whom he has a .793 OPS (.686 vs. lefties). Seager could excel when he faces Gonzalez at Texas' offense-inducing venue.
Clayton Kershaw (Dodgers): Kershaw has posted an astounding 1.96 ERA since the outset of the 2013 season, and he has compiled 205 strikeouts across 162 innings this year. The left-hander could post a game-changing total in DraftKings contests when he works at pitcher-friendly O.co Coliseum against an A's lineup that ranks 22nd in the Majors with a .683 OPS against southpaws.
James Shields (Padres): The right-hander -- who owns a 9.8 K/9 rate this season -- could compile several strikeouts and quality frames when he works at his pitcher-friendly home park against the Braves. Atlanta ranks 25th in the Majors with a .690 OPS against righties and last in baseball with 73 homers. The Braves' lack of power should especially benefit Shields, as his season-to-date 1.4 HR/9 rate is often a contributing factor in any rough outings.
Garrett Richards (Angels): The right-hander -- who owns a 3.04 ERA since the outset of last season -- could have a stellar outing when he works at his pitcher-friendly home park against a White Sox lineup that ranks 21st in baseball with a .701 OPS against righties. Richards may also come away with a win in a seemingly advantageous matchup with Danks (career 4.31 ERA, 1.34 WHIP).
R.A. Dickey (Blue Jays): Dickey has been red-hot since the All-Star break, going 4-0 with a 1.49 ERA across six starts. The right-hander could continue to excel when he faces a Phillies lineup that ranks 29th in the Majors with a .671 OPS against righties.
All statistics are accurate through the completion of Sunday's games.