"At this point, we're going to reevaluate him [Sunday] and see where he's at," said interim manager Torey Lovullo.
Sandoval led off the third and was hit on the first pitch by Mariners starter Felix Hernandez. Sandoval immediately began shaking his arm and went down in pain as Lovullo and trainer Brad Pearson raced out to check on him.
Brock Holt, who started the game at second base, replaced Sandoval at third to begin the fourth. Josh Rutledge took Holt's place at second.
Sandoval hit a solo home run to straightaway center field in his first at-bat in the second.
Quinn Roberts is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.