Yoenis Cespedes (Mets): Hitting .295 with 18 homers and 66 RBIs across 437 at-bats this season, the outfielder could thrive when he brings his balanced career splits into a matchup with Rockies left-hander Chris Rusin (lifetime 4.84 ERA, 1.53 WHIP). In his career, Rusin has allowed right-handed hitters such as Cespedes to post an .860 OPS (.724 OPS allowed to lefty batters).
Dee Gordon (Marlins): The second baseman could improve on his .326 batting average when he brings his career .695 OPS against right-handers (.639 vs. lefties) into a matchup with Red Sox righty Steven Wright (5.00 FIP in 2015). With 98 swipes since the outset of last season, Gordon has the wheels to compile multiple steals against Boston's knuckleballer.
Mike Trout (Angels): Hitting .302 with 33 homers across 398 at-bats this season, the outfielder continues to be the gold standard among Major League hitters. Trout will be in position to improve on his lofty lifetime .284/.390/.525 slash line against left-handers when he faces rookie southpaw Carlos Rodon (5.00 ERA, 1.68 WHIP) at hitter-friendly U.S. Cellular Field.
Albert Pujols (Angels): The first baseman has handled left-handers to the tune of a .317/.408/.605 career slash line. Pujols -- who has hit 30 homers across 409 at-bats this season -- could excel when he faces the inexperienced Rodon at Chicago's hitter-friendly park.
C.J. Cron (Angels): In his career, the slugger has posted a .761 OPS against left-handers that exceeds his .717 mark vs. righties. Cron may drive in multiple runs when he tangles with Rodon. Also of note: Cron and his teammates will attempt to put balls into play against a White Sox squad that ranks 29th in the Majors with a .668 defensive efficiency ratio.
Jhonny Peralta (Cardinals): With 16 homers and 55 RBIs across 418 at-bats, the shortstop has been among the most productive players at his premium position this season. Peralta has the skills to reach base often when he brings his lifetime .796 OPS against left-handers (.745 vs. righties) into a matchup with Pirates southpaw Jeff Locke (career 4.08 ERA, 1.37 WHIP).
Jake Lamb (D-backs): In his career, the third baseman has posted a .740 OPS against right-handers in comparison to a .598 mark vs. lefties. Lamb could drive in multiple runs when he bats at his hitter-friendly home park against Phillies righty David Buchanan (lifetime 4.75 ERA, 1.42 WHIP). Also of note: Lamb and his teammates will attempt to put balls into play against a Phillies defense that ranks last in the Majors with a .664 defensive efficiency ratio.
Jose Bautista (Blue Jays): Since the outset of the 2010 season, the outfielder has registered a .267/.387/.556 slash line against right-handers and a .282/.407/.589 slash line at his hitter-friendly home park. From the three-hole in the highest-scoring lineup in the Majors, Bautista could drive in multiple runs at the expense of rookie righty Kendall Graveman (career 1.40 WHIP) and an A's bullpen that ranks 27th in baseball with a 4.21 ERA.
Ryan Howard (Phillies): The first baseman -- who has compiled 16 homers and 54 RBIs across 289 at-bats against right-handers this season -- could drive in multiple runs when he faces D-backs righty Jeremy Hellickson (5.02 ERA since 2013). In his career, Howard has registered an impressive .284/.375/.569 slash line against righties.
Josh Reddick (A's): The outfielder has long fared best vs. right-handers, against whom he has posted a lifetime .773 OPS (.672 vs. lefties). Reddick will be in position to drive in multiple runs when he vacates his pitcher-friendly home park and heads to offense-inducing Rogers Centre to face fly-ball-prone righty Drew Hutchison (career 4.81 ERA, 1.36 WHIP).
Stephen Vogt (A's): With 15 homers and 60 RBIs across 346 at-bats, the catcher has been among the most productive players at his premium position this season. Vogt will look to improve on his career .762 OPS against right-handers (.616 vs. lefties) when he faces Hutchison (5.42 ERA, 1.52 WHIP in 2015) at Toronto's hitter-friendly venue.
Ike Davis (A's): Hitting .239 with three homers across 205 at-bats this season, the first baseman could have an economical cost in DraftKings contests when he brings his lifetime .798 OPS against right-handers (.579 vs. lefties) into a matchup with Hutchison. Davis may be facing Hutchison at the right time, as the hurler has posted a 6.67 ERA across his past six starts.
Xander Bogaerts (Red Sox): The shortstop -- who is hitting .311 this season -- could improve on his career .841 OPS against left-handers (.639 vs. righties) when he faces Marlins southpaw Justin Nicolino, who will be making his third Major League start.
Taylor Jungmann (Brewers): The rookie righty has excelled in his initial Major League action to the tune of a 2.26 ERA and a 1.07 WHIP across 11 starts. Jungmann could compile several strikeouts and quality frames when he faces a Cubs lineup that ranks 25th in the Majors with a .689 OPS against righties and first in baseball with 1,007 whiffs.
Erasmo Ramirez (Rays): With a 3.83 ERA and a 1.10 WHIP, Ramirez has been a useful second starter for DraftKings participants on several occasions this season. The right-hander could excel at his pitcher-friendly home park against a Braves lineup that ranks 24th in the Majors with a .690 OPS against righties and last in baseball with 70 homers.
Zack Greinke (Dodgers): With a 1.71 ERA and a 0.85 WHIP, the right-hander has been arguably the best pitcher in baseball this season. Greinke -- who has posted a 2.10 ERA at his pitcher-friendly home park since joining the Dodgers at the outset of 2013 -- could continue to dominate the competition when he works at home against the Nationals.
Madison Bumgarner (Giants): Having posted an ERA between 2.77 and 3.37 in each season since 2010, the left-hander is the model of a consistent ace. Bumgarner has the skills to work effectively and accumulate several strikeouts when he works at his pitcher-friendly home park against an Astros lineup that ranks second in baseball with 989 whiffs.
All statistics are accurate through the completion of Sunday's games.