Alex Rodriguez (Yankees): With an impressive lifetime .302/.382/.559 slash line against right-handers, Rodriguez could belt his 25th homer of the season when he hits at home against Blue Jays fly-ball-prone righty Marco Estrada (career 1.3 HR/9 rate).
Mark Teixeira (Yankees): The first baseman has hit 24 homers across 246 at-bats against right-handers during his 2015 bounceback season, and that total has contributed to a .285/.363/.646 slash line in those matchups. Teixeira is poised to put a ball into the outfield seats when he faces Estrada at homer-happy Yankee Stadium.
Brian McCann (Yankees): With a lifetime .828 OPS against right-handers (.756 vs. lefties), the catcher is another Yankees slugger who is primed to take the homer-prone Estrada deep. Having compiled 18 homers and 65 RBIs across 311 at-bats this season, McCann has been among the most productive players at his premium position.
Robinson Cano (Mariners): Hitting .339 with eight homers across 124 at-bats since July 1, the second baseman is back on track after a slow start to the season. Cano could improve on his lofty lifetime .316/.364/.523 slash line against right-handers when he faces Rangers righty Colby Lewis (career 4.82 ERA, 1.37 WHIP).
Seth Smith (Mariners): Smith has produced pronounced career splits, with an .832 OPS against right-handers that exceeds his .617 mark vs. lefties. The outfielder will be in position to thrive against Lewis, who has allowed left-handed hitters such as Smith to post an .823 OPS (.725 OPS allowed to righty batters) over his career.
Kyle Seager (Mariners): With a career .794 OPS against right-handers (.691 vs. lefties), Seager will be poised to drive in multiple runs against Lewis (4.68 ERA in 2015). The third baseman could also succeed late in the game against a Rangers bullpen that ranks last in the Majors with a 4.62 ERA.
Will Venable (Padres): As a big leaguer, Venable has handled right-handers to the tune of a .748 OPS (.622 vs. lefties). The outfielder has the plate skills to excel against Phillies righty Jerome Williams (career 4.55 ERA, 1.39 WHIP), and he possesses the speed to swipe a base against catcher Carlos Ruiz, who has thwarted 10 of 48 would-be basestealers this season.
Yonder Alonso (Padres): Alonso owns notable career splits, with a .753 OPS against right-handers in comparison to a .656 mark vs. lefties. The first baseman could drive in multiple runs against Williams, who has struggled this season to the tune of a 6.09 ERA and a 1.70 WHIP. Also of note: Alonso and his teammates will attempt to put balls into play against a Phillies squad that ranks last in baseball with a .664 defensive efficiency ratio.
Jose Abreu (White Sox): With a career .320/.395/.575 slash line against left-handers, Abreu has proven to be among the best in baseball during those matchups. The first baseman could drive in multiple runs when he faces Royals southpaw Danny Duffy (4.04 ERA, 1.42 WHIP in 2015).
Michael Brantley (Indians): Since the outset of last season, the outfielder has registered a difference-making .329/.392/.514 slash line against right-handers. Brantley could display his power when he hits at home against Twins fly-ball-prone righty Phil Hughes (career 4.29 ERA, 1.2 HR/9 rate). He may also swipe his 12th bag of the season against catcher Kurt Suzuki, who has allowed more steals than all but three catchers in 2015.
Jose Iglesias (Tigers): Hitting .310, the shortstop has been a cost-effective option at a premium position for DraftKings participants on several occasions this season. Iglesias could improve on his career .798 OPS against left-handers (.665 vs. righties) when he faces Red Sox southpaw Henry Owens, who will be making his second career Major League start.
Max Scherzer (Nationals): With a 2.31 ERA and a 0.85 WHIP, the right-hander has been among the most dominant starters in the Senior Circuit this season. Scherzer could continue to silence the opposition when he works at his pitcher-friendly home park against a Rockies lineup that is tied for 20th in baseball with a .685 OPS on the road this season. He may also earn a win in a seemingly advantageous matchup with Yohan Flande (career 4.66 ERA).
Corey Kluber (Indians): Ranking fifth in the Majors with 176 strikeouts, Kluber has been a major factor in many 2015 DraftKings contests. The right-hander could post a game-changing stat line when he works at home against a Twins lineup that ranks 23rd in baseball with a .695 OPS against righties.
Shelby Miller (Braves): With a 2.44 ERA and a 1.16 WHIP, Miller has been among the most improved pitchers in the Majors this season. The right-hander will be in position to extend his 2015 success when he works at his pitcher-friendly home park against a Marlins lineup that ranks last in the Majors with a .653 OPS against righties.
Chris Bassitt (A's): The right-hander could be an economical second starter in DraftKings contests when he brings his career 3.14 ERA into a matchup at his pitcher-friendly home park against the Astros. Bassitt -- who has posted a 2.64 ERA across 47 2/3 innings this season -- has the opportunity to combine several strikeouts and quality frames, as Houston ranks second in baseball with 977 strikeouts.
All statistics are accurate through the completion of Friday's games.