Nelson Cruz (Mariners): The outfielder -- who has hit 71 homers since the outset of last season -- owns a career .915 OPS against left-handers that exceeds his .822 mark vs. righties. Cruz will be in position to drive in multiple runs when he faces Rangers southpaw Martin Perez, who has posted a 6.64 ERA and a 1.48 WHIP across four starts since returning from Tommy John surgery.
Jose Bautista (Blue Jays): Since the outset of the 2010 season, the outfielder has used a patient, powerful approach to register a .266/.387/.554 slash line against right-handers. From the three-hole in the highest-scoring lineup in baseball, Bautista could thrive against Yankees righty Ivan Nova (career 4.12 ERA, 1.38 WHIP).
Ian Kinsler (Tigers): The second baseman has traditionally excelled vs. left-handers, against whom he has registered an .877 OPS (.762 vs. righties). Kinsler may reach base often and score multiple runs when he faces Red Sox southpaw Wade Miley, who owns a season-to-date 4.55 ERA and a 1.39 WHIP.
Jose Iglesias (Tigers): The shortstop -- who is hitting .314 this season -- could improve on his career .798 OPS against left-handers (.671 vs. righties) at the expense of Miley (career 1.33 WHIP). Also of note: Iglesias and his teammates will attempt to put balls into play against a Red Sox squad that ranks 25th in the Majors with a .680 defensive efficiency ratio.
David Ortiz (Red Sox): The slugger is primed to improve on his lofty lifetime .292/.396/.575 slash line against right-handers when he faces Tigers righty Alfredo Simon, who owns a season-to-date 4.55 ERA and a 1.43 WHIP. This season, Ortiz has hit 18 homers across 249 at-bats against righties.
Melky Cabrera (White Sox): Hitting .392 with 20 RBIs across 74 at-bats since July 18, the outfielder is one of the hottest hitters in baseball. Cabrera could continue to thrive when he faces Royals righty Jeremy Guthrie, who has posted a 5.65 ERA and a 1.57 WHIP during an uneven 2015 season.
Justin Upton (Padres): With 18 homers and 17 steals across 421 plate appearances this season, Upton possesses the diverse skill set that DraftKings participants covet. The outfielder has the plate skills to reach base often when he brings his lifetime .888 OPS against left-handers (.802 vs. righties) into a matchup with Phillies rookie southpaw Adam Morgan (4.46 ERA, 1.43 WHIP). He could also swipe a bag against catcher Carlos Ruiz, who has thwarted 10 of 48 would-be basestealers this season.
Derek Norris (Padres): As a big leaguer, the catcher has excelled against left-handers to the tune of an .833 OPS (.643 vs. righties). Norris could be part of a Padres stack -- with Upton and outfielder Matt Kemp -- against the inexperienced Morgan (5.63 FIP).
Paul Goldschmidt (D-backs): Hitting .339 with 22 homers and 19 steals across 471 plate appearances, the first baseman has arguably been the most productive hitter in baseball this season. Goldschmidt will be primed to improve on his career .290/.385/.507 slash line against right-handers when he bats at his hitter-friendly home park against Reds rookie righty Keyvius Sampson, who has thrown just six Major League innings.
Jake Lamb (D-backs): The third baseman -- who was a career .321 hitter in the Minors -- has produced a lifetime .746 OPS against big league right-handers that exceeds his .580 mark vs. lefties. Lamb could drive in multiple runs against the inexperienced Sampson, who registered a 4.17 ERA and a 1.34 WHIP during his Minor League career.
Matt Cain (Giants): With a season-to-date 4.91 ERA, the right-hander may have an economical price tag in DraftKings contests for a matchup against the Cubs. Among big league clubs, Chicago ranks 25th with a .683 OPS against righties and at the top with 982 strikeouts.
Noah Syndergaard (Mets): The rookie righty has excelled in his initial Major League action to the tune of a 2.66 ERA and a 1.06 WHIP across 15 starts. Syndergaard may continue to excel when he works at pitcher-friendly Tropicana Field against a Rays lineup that ranks 28th in baseball with a .674 OPS against righties.
Jaime Garcia (Cardinals): With a 1.98 ERA and a 0.92 WHIP, Garcia has been a cost-effective second starter in several 2015 DraftKings contests. The left-hander could silence the opposition when he faces a Brewers lineup that ranks 25th in the Majors with a .656 OPS against southpaws. Upon leaving the game, Garcia could receive strong support from a St. Louis relief corps that sits first in baseball with a 2.26 ERA.
Mike Foltynewicz (Braves): DraftKings participants seeking an economical second starter may opt for Foltynewicz in spite of his career 5.38 ERA. The right-hander could compile quality frames when he works at his pitcher-friendly home park against a Marlins lineup that ranks last in the Majors with a .653 OPS against righties.
Tyson Ross (Padres): With a 3.03 ERA since the outset of last season, Ross can be a trusted No. 1 starter for DraftKings participants when he works at his pitcher-friendly home park against a Phillies lineup that ranks 29th in baseball with a .673 OPS against righties. Ross could easily come away with a win if his supporting cast succeeds against the inexperienced Morgan.
All statistics are accurate through the completion of Thursday's games.