"I felt like I put us in that situation in the ninth and just grateful for the opportunity to come up there in the 10th and come through," said Lowrie, who spent the previous two seasons with the A's.
The hit was only one of two for the Astros with runners in scoring position. Carlos Correa hit a two-run homer in the eighth to help the Astros to a 4-2 lead, but Lowrie's miscue in the ninth was costly. Houston closer Luke Gregerson walked Stephen Vogt to start the inning and then got Brett Lawrie to hit a grounder to Lowrie, but his throw to second sailed wide of the bag.
The A's had runners on the corners and scored on a single by Ike Davis and a fielder's choice off the bat of Billy Burns, who narrowly beat the throw to first to avoid would have been a game-ending double play. Astros second baseman Jose Altuve led off the 10th with a single, stole second and was at third with two outs when Lowrie doubled to left field.
"I feel responsible for the inning like that," Lowrie said. "You got an opportunity to get the lead runner right there and you know instead of having a guy on first with one out, they've got first and third nobody out."
Lowrie was making only his sixth start at third base since returning from a thumb injury that cost him more than three months. He was playing shortstop when he was injured, but the emergence of Correa at short forced him to switch positions upon his return.
He wasn't about to make any excuses about learning a new position.
"I'm not going to say no, but it's just a [bad] throw," he said. "There's really no other way to say it. It's definitely not acceptable, but you know I just need to continue to work at it."
The Astros had struggled in the clutch during a three-game sweep at the hands of the Rangers, going 3-for-20 with runners in scoring position in one-run losses on Tuesday and Wednesday.
"Even though we lost those three games in Texas, we fought through some tough times, we were never out of those games," Lowrie said. "I think that's the mark of a good team. So for us to come back and win this one, I think that's a good first step."
Brian McTaggart is a reporter for MLB.com and writes an MLBlog, Tag's Lines. Follow @brianmctaggart on Twitter and listen to his podcast. This story was not subject to the approval of Major League Baseball or its clubs.