Preston Tucker (Astros): The rookie outfielder has excelled vs. right-handers, smacking 10 homers and posting a .924 OPS against them (.443 vs. lefties. He's set up to perform well when he meets up with righty Colby Lewis (career 4.79 ERA) and a Rangers relief corps that ranks last in the Majors with a 4.71 ERA.
Luis Valbuena (Astros): Since the start of the 2014 season, Valbuena has posted a .783 OPS against right-handers (.612 vs. lefties). The third baseman may hit his 20th homer of the season at offense-inducing Globe Life Park in Arlington against Lewis, who in his career has allowed left-handed hitters such as Valbuena to register an .819 OPS (.724 OPS allowed to righty batters).
Jose Bautista (Blue Jays): Since the outset of the 2010 season, the outfielder has produced a .267/.388/.555 slash line against right-handers and a .283/.410/.592 slash line at hitter-friendly Rogers Centre. He will be primed to rip a roundtripper when he brings his patient, powerful approach into a home matchup against Twins righty Ervin Santana (career 1.28 WHIP, 1.2 HR/9 rate).
Matt Duffy (Giants): Hitting .305 with nine homers and 48 RBIs across 325 at-bats, the third baseman has been a cost-effective option for DraftKings participants on many occasions this season. He could thrive when he brings his lifetime .801 OPS against right-handers (.714 vs. lefties) into a matchup with righty Mike Foltynewicz (career 5.11 ERA, 1.59 WHIP) and a Braves relief corps that ranks 25th in baseball with a 4.12 ERA.
Yonder Alonso (Padres): Alonso has a career .757 OPS against right-handers that exceeds his .661 mark vs. lefties. The first baseman could drive in multiple runs against Peralta, who in his career has allowed left-handed hitters such as Alonso to post a .789 OPS (.658 OPS allowed to righty batters).
Seth Smith (Mariners): With a career .833 OPS against right-handers (.619 vs. lefties), the outfielder will be in position to succeed away from his pitcher-friendly home park when he faces righty Eddie Butler (lifetime 5.20 ERA, 1.80 WHIP) at homer-happy Coors Field.
Kyle Seager (Mariners): As a big leaguer, Seager has handled right-handers to the tune of a .793 OPS (.691 vs. lefties). The third baseman will be in position to display his power when he meets up with Butler (4.82 ERA, 1.78 WHIP in 2015) and a Rockies bullpen that sits 29th in baseball with a 4.53 ERA.
Brad Miller (Mariners): With a lifetime .746 OPS against right-handers (.561 vs. lefties), the shortstop could be an economical addition to a Mariners lineup against Butler. Of note: Miller and his teammates will attempt to put balls into play against a Rockies squad that ranks 28th in the Majors with a .674 defensive efficiency ratio.
Stephen Vogt (A's): With 14 homers and 58 RBIs in 324 at-bats, the catcher has been one of the most productive players at his premium position this season. He could drive in multiple runs when he puts his lifetime .762 OPS against right-handers (.628 vs. lefties) on the line against Orioles righty Tyler Wilson, who will be making his second career start.
Bryce Harper (Nationals): Hitting .332 with 29 homers and 68 RBIs in 328 at-bats, Harper has been one of baseball's best hitters this season. The outfielder could improve on his lifetime .931 OPS against right-handers (.771 vs. lefties) when he faces D-backs righty Zack Godley, who will be making his third Major League start.
Evan Longoria (Rays): The third baseman has notable career splits, with a .916 OPS against left-handers compared with an .807 mark vs. righties. He has the skills to reach base often at the expense of Jose Quintana (career 1.26 WHIP) at hitter-friendly U.S. Cellular Field.
Tom Koehler (Marlins): With a 2.40 ERA and 0.96 WHIP in his past seven starts, Koehler has been an effective second starter in many recent DraftKings contests. The right-hander could continue his summer surge when he works at his pitcher-friendly home park against a Mets lineup that ranks 28th in baseball with a .669 OPS vs. righties.
Bartolo Colon (Mets): DraftKings participants who do not select Koehler may instead opt for his mound opponent. With a 4.96 ERA, the right-hander could have a reduced price tag in DraftKings contests when he heads to offense-suppressing Marlins Park to face a Miami lineup that ranks last in the Majors with a .651 OPS vs. righties. Colon may be facing the Marlins at the right time, as the team will be without offensive centerpiece Giancarlo Stanton, who is on the disabled list.
Garrett Richards (Angels): The right-hander -- who has produced a 2.93 ERA since the outset of last season -- has the opportunity to spin a gem when he faces the Indians at his pitcher-friendly home park. The Tribe ranks 19th in the Majors with a .701 OPS against righties.
Matt Cain (Giants): With a 4.50 ERA, the right-hander may be an economical option in DraftKings contests for a start at pitcher-friendly Turner Field against a light-hitting Braves lineup that ranks last in baseball with 63 homers. Cain -- who will be supported by a Giants squad that ranks sixth in the Majors with a .704 defensive efficiency ratio -- could come away with a win in a seemingly advantageous matchup with Foltynewicz.
All statistics are accurate through the completion of Saturday's games.
This story was not subject to the approval of Major League Baseball or its clubs.