"David was sent home before the game and was not available in any capacity today," said Red Sox manager John Farrell. "This came on throughout the game [Saturday] night. Was checked here this morning and doctors' instructions was to leave the ballpark."
The Red Sox waited until roughly 90 minutes before game time to post the lineup, hoping that pumping some fluids into Ortiz would enable him to play.
But the lineup that Farrell posted had Travis Shaw at first base and Hanley Ramirez at designated hitter.
Alejandro De Aza played left field and Shane Victorino got the nod in right field.
Farrell hopes Ortiz will be better by Friday, when the Red Sox open a seven-game road trip in Anaheim.
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, follow him on Twitter @IanMBrowne and listen to his podcast. This story was not subject to the approval of Major League Baseball or its clubs.