Here are five games to watch:
Sale goes for the record books: TOR @ CWS, 8:10 p.m. ET
Sale is in one of the most dominant pitching stretches in the game's long history. In his start on Tuesday against the Cards, he struck out 12 to join Hall of Famer Pedro Martinez as the only pitchers in Major League history to strike out 10 or more batters in eight straight starts. On Monday, he looks to make it nine.
Sale is 3-3 with a 1.80 ERA and 97 strikeouts over 60 innings during his streak.
Sale faces a powerful Blue Jays offense, while former White Sox starter Mark Buehrle takes the mound for Toronto.
Keuchel faces Tribe: HOU @ CLE, 7:10 p.m. ET
Keuchel has turned in two consecutive scoreless starts, the first a 12-strikeout shutout against the Yankees before blanking the Royals over eight innings his last time out.
Keuchel opened the season by scattering three hits over seven scoreless innings against the Indians on Opening Day.
The crowd at Progressive Field should be in for a pitchers' duel, as righty Carlos Carrasco takes the ball for the Indians. Carrasco fanned 13 over 8 2/3 innings his last time out, against the Rays, losing his no-hit bid with two outs in the ninth.
Cardinals, Cubs meet again, 8:05 p.m. ET
The last time the Cubs saw the Cardinals, the two-time reigning National League Central champions put the baby bears in their place with a three-game sweep at Busch Stadium. Chicago has since righted the ship, but still sits in third place behind St. Louis and Pittsburgh.
The Cubs are back at Wrigley this time as they try to prove they can hang with their division rivals, beginning with Monday night's matchup of Cardinals right-hander John Lackey (6-5, 3.30 ERA) and Cubs lefty Jon Lester (4-6, 3.74 ERA).
Brewers go for nine straight: ATL @ MIL, 8:10 p.m. ET
After a rough start to the season -- which led to a managerial change -- and a first half mostly spent playing catch-up, Milwaukee is all of a sudden the hottest team in baseball. On Monday, the Brewers go for their ninth straight win when they open a series against Atlanta.
Right-hander Kyle Lohse, who is 5-2 with a 3.91 ERA in 13 career starts against the Braves, takes the mound for the Brewers. He'll be up against Braves rookie righty Matt Wisler, who is making his fourth career start.
Heston hopes history repeats: NYM @ SF, 10:15 p.m. ET
Giants right-hander Chris Heston faces the team that helped him etch his name in baseball history. Heston no-hit the Mets on June 9 at Citi Field, striking out a career-high 11, walking none and hitting three batters.
Left-hander Jon Niese (3-8, 3.90 ERA) gets the start for the Mets at AT&T Park. Niese has a career ERA of 2.92 in eight games (seven starts) against the Giants, but sports a 1-3 record.