Jason Castro (Astros): The catcher has produced pronounced lifetime splits, with a .753 OPS against right-handers in comparison to a .563 mark vs. lefties. Castro could drive in multiple runs when he faces Red Sox righty Justin Masterson (5.80 ERA since 2014).
Miguel Cabrera (Tigers): The first baseman could rip a round-tripper when he brings his lofty lifetime .322/.389/.564 slash line against right-handers into a matchup with Blue Jays fly-ball-prone righty Drew Hutchison (career 4.64 ERA, 1.32 WHIP).
Adam Lind (Brewers): Lind has long fared best vs. right-handers, against whom he has registered a career .864 OPS (.590 vs. lefties). The first baseman could smack a homer when he meets up with rookie righty Michael Lorenzen (5.69 FIP) at homer-happy Great American Ball Park.
Gerardo Parra (Brewers): The outfielder could reach base often when he brings his lifetime .761 OPS against right-handers (.598 vs. lefties) into a matchup with Lorenzen (career 1.45 WHIP) at an offense-inducing venue. He could also swipe his sixth base of the campaign against catcher Brayan Pena, who has thrown out five of 33 would-be basestealers this season.
Scooter Gennett (Brewers): Gennett has some of the most lopsided splits in baseball, with an .824 OPS against right-handers that greatly exceeds his .305 mark vs. lefties. Set to face a rookie righty in Cincinnati's Lorenzen, the second baseman could be part of an economical Brewers stack.
Cameron Maybin (Braves): Hitting .303 with 31 RBIs and 12 steals across 221 plate appearances since May 1, the outfielder has been a recent factor in many DraftKings contests. Maybin could improve on his lifetime .695 OPS against right-handers (.649 vs. lefties) at the expense of Correia (career 4.58 ERA, 1.42 WHIP). He could also swipe a base against catcher Carlos Ruiz, who has stopped just seven of 39 basestealers this season.
David Ortiz (Red Sox): After a slow start to the season, the slugger rediscovered his power stroke by collecting seven homers and 18 RBIs across 93 at-bats during June. Ortiz could improve on his impressive career .292/.396/.575 OPS against right-handers when he faces Astros righty Dan Straily (career 4.54 ERA, 1.31 WHIP).
Matt Wieters (Orioles): As a big leaguer, the catcher has handled left-handers to the tune of an .824 OPS (.715 vs. righties). Wieters may provide notable production from his premium position when he faces White Sox southpaw John Danks (career 4.34 ERA, 1.34 WHIP).
J.J. Hardy (Orioles): One of few shortstops with notable power, Hardy could rip a round-tripper or drive in multiple runs when he brings his lifetime .774 OPS against left-handers (.715 vs. righties) into a matchup with Danks (5.38 ERA, 1.48 WHIP in 2015). Of note: Hardy and his teammates will attempt to put balls into play against a White Sox defense that ranks last in the Majors with a .660 defensive efficiency ratio.
David Peralta (D-backs): With noticeable career splits -- such as an .842 OPS against right-handers opposed to a .538 mark vs. lefties -- the outfielder could excel when he hits at his offense-friendly home park against Rockies righty Kyle Kendrick (6.07 ERA in 2015). Peralta could also excel late in the game against a Colorado bullpen that ranks last in baseball with a 4.73 ERA.
Jake Lamb (D-backs): In his brief career, Lamb has registered a .724 OPS against right-handers that exceeds his .503 mark vs. lefties. The third baseman could thrive against Kendrick, who as a big leaguer has allowed left-handed batters such as Lamb to post an .826 OPS (.744 OPS allowed to righty hitters).
Paul Goldschmidt (D-backs): Hitting .350 with 20 homers, 65 RBIs and 15 steals across 344 plate appearances, Goldschmidt arguably has been the most productive fantasy asset this season. The first baseman could improve on his career .290/.384/.515 slash line against right-handers and his lifetime .287/.394/.524 slash line at Chase Field when he faces Kendrick (career 1.37 WHIP).
Julio Teheran (Braves): With a season-to-date 4.94 ERA, the right-hander could have an economical price tag in DraftKings contests when he works at his pitcher-friendly home park. He will be facing the Phillies, who rank 28th in the Majors in runs per game (268) and last in OPS vs. righties (.639).
Michael Wacha (Cardinals): Despite a less-than-elite strikeout rate, the right-hander has emerged as the ace of the winningest club in baseball this season by producing a 2.77 ERA and a 1.10 WHIP. Wacha could continue to compile quality frames when he plies his trade at home against a Padres lineup that sits 26th in the Majors with a .666 OPS against righties. Upon leaving the game, Wacha may be well-supported in his quest for a win by a St. Louis bullpen that ranks second in baseball with a 2.15 ERA.
Jesse Chavez (A's): With a 3.27 ERA across 13 starts since rejoining the rotation on April 23, the right-hander has made the most of his second chance as a starter. On Friday, Chavez could excel at his pitcher-friendly home park against a Mariners lineup that ranks 28th in baseball in OPS against righties (.659) and 29th overall in runs (267).
Clayton Kershaw (Dodgers): The left-hander -- who has a 2.08 ERA with a 10.2 K/9 rate since the outset of 2013 -- has been a difference-maker in many DraftKings contests this season. Kershaw could continue to dominate the competition when he works at his pitcher-friendly home park against a Mets lineup that sits 27th in the Majors with 276 runs.
All statistics are accurate through the completion of Wednesday's games.