When he took a no-hitter into the eighth inning against the Rays in his last start, Blue Jays right-hander Marco Estrada became the first pitcher since Dave Stieb in 1988 to do it in back-to-back games. What does he have in store for part three? He'll be up against Red Sox left-hander Eduardo Rodriguez, who gave up six earned runs in 3 2/3 innings in his last start.
• Division leaders duel: KC @ HOU, 8:10 p.m. ET
Astros left-hander Dallas Keuchel will carry a 9-3 record and 2.17 ERA, the AL's second-best mark, into a matchup with Royals lefty Danny Duffy as the American League West and Central leaders meet at Minute Maid Park. Keuchel is coming off a 12-strikeout shutout against the Yankees on Thursday, while Duffy returned to Kansas City's rotation Wednesday by allowing two runs (one earned) over 4 2/3 innings against Seattle.
• Verlander back again: PIT @ DET, 7:08 p.m.
After a stiff back held him out of his last scheduled start, Tigers right-hander Justin Verlander is returning for this Rust Belt showdown against the Pirates. Gerrit Cole, starting for Pittsburgh, is 6-1 lifetime in Interleague Play.
• Niese streaking the wrong way: CHC @ NYM, 7:10 p.m. ET
Mets left-hander Jon Niese will try to kick a sad streak when he faces Kyle Hendricks and the Cubs on Tuesday. Niese, who has thrown four straight quality starts, hasn't won since May 9 and has seen the Mets go 1-7 during his five-game losing skid. To make matters worse, Niese has a 5.23 ERA in nine starts against Chicago.
• Sale still sailing: CWS @ STL, 8:15 p.m. ET
White Sox left-hander Chris Sale has gone a remarkable seven straight starts with at least 10 strikeouts. Over his last nine outings overall, the southpaw has racked up 103 strikeouts in 68 innings while walking just 11. The first-place Cardinals will be his test tonight.
Joey Nowak is a reporter for MLB.com. Follow him on Twitter at @joeynowak. This story was not subject to the approval of Major League Baseball or its clubs.