Colby Rasmus (Astros): Rasmus has produced notable career splits, with a .789 OPS against right-handers in comparison to a .661 mark vs. lefties. The outfielder could drive in multiple runs when he hits at home against Yankees righty Nathan Eovaldi, who has posted a 4.95 ERA and a 1.57 WHIP this season.
Brett Gardner (Yankees): With 26 homers and 36 steals since the outset of the 2014 season, the outfielder could produce in multiple ways when he faces Astros right-hander Vincent Velasquez. The rookie hurler was unable to pitch into the sixth inning during each of his initial three Major League starts, and Gardner is red-hot this month with a .326 average, five homers, 17 RBIs and 24 runs across 100 plate appearances.
Brian McCann (Yankees): McCann could drive in multiple runs when he puts his career .834 OPS against right-handers (.751 vs. lefties) on the line against Velasquez. The catcher could be part of a productive lineup against the inexperienced right-hander, as the Yankees rank third in the Majors with a .770 OPS vs. righties.
Jose Bautista (Blue Jays): Since the outset of the 2010 season, Bautista has produced a .268/.391/.555 slash line against right-handers and a .285/.412/.594 slash line at his hitter-friendly home park. From there, he could showcase his power or reach base often out of his premium lineup position against Rangers righty Nick Martinez (career 1.41 WHIP).
Edwin Encarnacion (Blue Jays): From the cleanup spot, Encarnacion could be involved in plenty of run scoring when he leads baseball's highest-scoring lineup into a matchup with Martinez (career 4.70 FIP). Since the outset of 2012, the first baseman has registered a .270/.370/.542 slash line at Rogers Centre and a .266/.357/.533 slash line against righties.
Giancarlo Stanton (Marlins): With a career .291/.384/.616 slash line against left-handers, Stanton has proven to wield a potent bat in those matchups. The outfielder could use his patient, powerful approach to have a big game against Dodgers southpaw Brett Anderson (1.33 WHIP in 2015).
Ian Kinsler (Tigers): The second baseman has long fared best vs. left-handers, against whom he has a lifetime .873 OPS (.757 vs. righties). From a likely spot in the two-hole, he could reach base several times against White Sox southpaw Jose Quintana (career 1.27 WHIP).
Victor Martinez (Tigers): Because he has hit .228 and dealt with a knee injury this season, Martinez could carry an economical DraftKings price tag into a matchup with Quintana. As a big leaguer, the slugger has handled left-handers to the tune of a .307/.377/.490 slash line. Also of note: Martinez and his teammates will attempt to put balls into play against a White Sox unit that ranks last in baseball with a .660 defensive efficiency ratio.
Rajai Davis (Tigers): Davis owns pronounced lifetime splits, with an .812 OPS against left-handers that exceeds his .647 mark vs. righties. The outfielder could reach base often against Quintana (1.35 WHIP in 2015) or swipe a bag against catcher Tyler Flowers, who has allowed more steals than all but five catchers in 2015.
Jose Iglesias (Tigers): With a career .816 OPS against left-handers (.654 vs. righties), the shortstop could be an economical portion of a Tigers stack against Quintana. With several hitters who fare best against left-handers -- including the incredible Miguel Cabrera -- Detroit ranks third in baseball this season with a .754 OPS vs. southpaws.
Neil Walker (Pirates): The second baseman could improve on his lifetime .796 OPS against right-handers (.654 vs. lefties) when he faces Braves rookie righty Williams Perez (4.35 FIP, 1.37 WHIP). Walker could also have success against an Atlanta bullpen that ranks 28th in the Majors with a 4.41 ERA.
Max Scherzer (Nationals): Many DraftKings participants will want to make a major expenditure on Scherzer, who has allowed one hit and one walk across 18 shutout innings during his past two starts. The right-hander could post a third straight memorable outing when he faces a Phillies lineup that ranks 29th in baseball in runs (244) and last in OPS against righties (.636).
Kyle Lohse (Brewers): With a season-to-date 6.30 ERA, the right-hander could be an economical second starter for DraftKings participants when he faces a Minnesota lineup that ranks 23rd in the Majors with a .675 OPS against righties. Lohse may be getting the Twins at the right time, as they rank 24th in baseball with 76 runs in June and will have to work without the designated-hitter spot at Miller Park.
Tyson Ross (Padres): Ross -- who posted a 2.81 ERA a year ago -- has produced a 3.61 ERA this season despite owning an unusually high .357 BABIP. The right-hander is coming off a strong start, during which he allowed one run in a complete-game win at offense-inducing Chase Field. Looking ahead to Friday, he could compile quality frames at his pitcher-friendly home park during a rematch with the righty-heavy D-backs lineup.
Francisco Liriano (Pirates): Liriano has excelled this season, posting a 2.96 FIP, a 0.98 WHIP and 105 strikeouts across 88 1/3 innings. The left-hander could continue to excel when he works at his pitcher-friendly home park against a Braves lineup that ranks 29th in baseball with a .632 OPS against southpaws.
All statistics are accurate through the completion of Wednesday's games.