De Paula, 27, was 2-0 with a 1.53 ERA in three starts for the RailRiders. Yankees manager Joe Girardi said that De Paula could see his first Major League action as a long reliever in place of Chris Capuano, who threw 77 pitches in Tuesday's 12-2 loss to the Marlins.
"He's a guy that can give us distance," Girardi said. "He's a guy that has some experience. He's been starting down there. He's stretched out. We're without Cap for, you have to assume at least three days probably. We needed somebody who could give us some real distance."
In a corresponding roster move, the Yankees optioned right-hander Jose Ramirez to Triple-A. Ramirez, 25, has no record and a 15.00 ERA in three appearances for New York this year.
Bryan Hoch is a reporter for MLB.com. Follow him on Twitter @bryanhoch, on Facebook and read his MLBlog, Bombers Beat. This story was not subject to the approval of Major League Baseball or its clubs.