San Diego also recalled right-hander Cory Mazzoni from Triple-A El Paso to take Myers' place on the active roster.
As for Myers, the 24-year-old outfielder had been out since May 10 with the same injury before returning last Thursday. He played just three games before sitting out on Sunday's contest and ultimately landing back on the DL on Monday.
Myers is hitting .277/.327/.459 with five homers and 19 RBIs over 35 games in his first season with the Padres.
He said after returning last week that he anticipates eventually needing offseason surgery to remove a bone spur from the troublesome wrist, though he didn't think it wouldn't be a necessity during the season.
It's unclear at this point how long Myers will be sidelined with this latest setback or what the plan will be going forward.
Paul Casella is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.