The catcher crushed a two-out, three-run home run to right field in the sixth inning as Orioles left-hander Wei-Yin Chen threw eight scoreless innings. The O's (32-31) have won nine of their last 11 games to move over the .500 mark. They can improve to two games over .500 for the first time since April 19 with a victory Tuesday.
"I chased a pitch on 1-1, so I wanted to get something that was going to stay in the zone, and he threw a breaking ball that was probably a lot more of the zone than he wanted to throw," Wieters said.
The Phillies, meanwhile, couldn't support starter Aaron Harang, falling to 0-7 on their eight-game road trip and losing their 17th in their last 20 games.
"I think everybody is grinding through it," said Harang, who watched teammate Maikel Franco get ejected in the seventh inning. "We've all had our bad days. Sometimes you just have to snap and let the frustration out. Sometimes it's good, because if you leave it pent up too long, you can start pressing even more. It's good to let that out. It shows that you really care."
MOMENTS THAT MATTERED Wieters breaks it open: Wieters provided the Orioles with a spark in the sixth on a relatively slow night for the Baltimore offense. The catcher drove a 1-2 pitch over the tall right-field scoreboard to give the O's a 4-0 lead and pick up his second home run of the season after returning to the team on June 5. Baltimore had just four hits prior to Wieters' homer.
"It's a different level of pitching, a different level of intensity, but I thought that would be something that should come fairly quickly," Orioles manager Buck Showalter said. "Matt, especially a couple games, you could tell he was getting the bat to the right places." More >
Franco shows emotions, offense flatlines: Franco has been the team's best hitter since he joined the team on May 15, but he earned his first big league ejection in the seventh after arguing a called third strike in a heated exchange with home-plate umpire Eric Cooper. The rest of the offense continued to struggle. Since the Phillies scored in the fourth inning Wednesday in Cincinnati, they have scored just three runs in 47 innings. That includes three shutouts in their last four games.
"There is nothing you can do about it; it's already over," Franco said about the ejection. "So tomorrow we can try to come in positive with a lot of energy, stay with it, stay strong and try to do something to win the game." More >
Chen goes eight: Chen picked up his second consecutive win with an impressive outing in Baltimore. The left-hander threw eight innings for just the fourth time in his career, allowing four hits and one walk while tying a season-high with nine strikeouts. Chen posted his first scoreless start of the season and did not face more than four batters in any inning. He picked up his eighth quality start of the season, which is the most of any Orioles pitcher.
"I felt great, and all my pitches were working today, and Wieters [called] a great game for me and my teammates played [great] defense behind me," Chen said. More >
One mistake sinks Harang: Harang appeared to have straightened out things until Wieters' home run. He had allowed just one run in his first five innings -- he had allowed 13 runs in 11 2/3 innings in his last two starts -- and that run scored after Cody Asche could not make a play near the left-field wall on Travis Snider's double in the fifth.
"One pitch," Harang said. "A flat, cement-mixer slider up there to Wieters."
"I don't know. You never know when things are going to happen." -- Harang, on the possibility of being traded to a contender in the coming weeks
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The Phillies need to win Tuesday night to avoid their first winless road trip of eight or more games in franchise history. They have had five 0-7 road trips in franchise history, and nine road trips of eight or more games with just one victory.
WHAT'S NEXT Phillies: Phillies right-hander Jerome Williams has been struggling for a while, but he hopes to change that Tuesday night at 7:05 p.m. ET against the Orioles. He allowed four runs in six innings last week in a loss to the Reds, and he has a 6.70 ERA in his last nine starts.
Orioles:Chris Tillman will get the start on Tuesday before the two teams head to Philadelphia for another two-game series. The right-hander is riding a two-game winning streak after collecting six straight losses prior. He is coming off a win against the Red Sox where he lasted 5 2/3 innings, allowing five hits, four runs and two walks while striking out two.
Todd Zolecki is a reporter for MLB.com. Read his Phillies blog The Zo Zone, follow him on Twitter and listen to his podcast. Connor Smolensky is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.