CHICAGO -- Eugenio Suarez hit a tiebreaking RBI single with one out in the 10th and Todd Frazier drove in two runs, including one on his 18th home run, to lead the Reds to a 5-4 victory over the Cubs on Friday in front of 40,016, the largest crowd of the season at Wrigley Field.
With the game tied at 4 in the Reds' 10th, Frazier led off by reaching on a fielding error by third baseman Kris Bryant, who had trouble picking up the grounder. Frazier reached third on Jay Bruce's single to right, and one out later, Suarez, promoted on Thursday from Triple-A Louisville, singled to left, his second hit of the season and first RBI in his eighth at-bat.
The Reds had opened a 4-2 lead, helped by Frazier, who hit an RBI double in a three-run first and a solo home run in the third. But Starlin Castro tied the game at 4 with a two-run homer in the sixth off Johnny Cueto that cleared the left-field bleachers and landed on Waveland Avenue.
The win was Cincinnati's fifth in six games, despite missing more than half of its Opening Day starting roster.
"We're just doing what we can, honestly," Bruce said. "I think we've been playing well, but the season doesn't stop, the games don't stop and we have to figure out a way. The best teams do. We're just kind of putting our heads down and rolling. We don't really have a choice."
MOMENTS THAT MATTERED Up and down Johnny: Cueto had an adventurous day. He struck out nine over seven innings, including the side in the third. Then, the right-hander singled to lead off the fourth but collided with first baseman Anthony Rizzo at first. Cueto stayed in the game, but did not get a decision after allowing Castro's homer. The Cubs' seven hits marked the third time Cueto had allowed more than six hits since May 3.
"He battled his tail off, as always," Reds manager Bryan Price said. "He doesn't shy away from pitching in close games at all."
Double the doubles: The Reds struck early thanks to a pair of RBI doubles from the top of their lineup. Ivan De Jesus Jr. hit a double to left field to easily score Skip Schumaker from second. Two batters later, Frazier doubled to center field to score De Jesus Jr. Cincinnati scored three runs in the first inning, forcing Cubs starter Jason Hammel to make 37 pitches in the frame.
Hammel battles: In his 11 previous starts, Hammel had given up two runs total in the first inning, but the Reds scored three on Friday, taking advantage of an error by second baseman Addison Russell. Hammel departed after throwing 103 pitches over five innings. He tried to help himself, hitting an opposite-field RBI single in the second. Hammel now is 8-for-32 at the plate this season while starters Jon Lester, Jake Arrieta and Kyle Hendricks are a combined 2-for-75.
"I was just out of sync today," Hammel said. "I wasn't on top of the baseball like I have been and it cost me a lot of deep counts, and basically I battled for five innings. The fact we had a chance to still be in it and win was nice because it could've been a lot worse." More >
"I think the catalyst to everything was the catch Jay Bruce made in right field -- a game saver. Really, I think it gave us some momentum back after the home run by Castro, and gave us the momentum back and put us in a position to win that game." -- Price, on Bruce's diving catch in right field to help send the game to the 10th inning
"If we play that [type of] game every night, I'll accept that. You talk about effort and 'want to' and all the other stuff you're looking for, the will to win -- we made some physical mistakes, and that's going to happen, you're going to make mistakes, but if we play that game often enough this year, we'll definitely get ourselves to the playoffs." -- Maddon
SOUND SMART WITH YOUR FRIENDS
Reds first baseman Joey Votto extended his on-base streak to 21 games after he was intentionally walked by Hammel in the fourth inning. Votto is now tied for the Majors' second-longest active on-base streak.
Castro's home run was his first at Wrigley Field since June 20, 2014, against the Pirates. His previous seven home runs were all on the road.
CUETO VS. RIZZO
Anthony Rizzo's .327 batting average entering Friday's game was one of his best marks in his career, but the Cubs' first baseman met his kryptonite with Cueto on the mound. After a two-strikeout, 0-for-4 performance against the Reds' starter, Rizzo is now batting .090 (2-for-22) with seven strikeouts against Cueto in his lifetime.
WHAT'S NEXT Reds:Mike Leake will see the Cubs for a third time this season when the Reds continue their road trip on Saturday at 7:15 p.m. ET at Wrigley Field. Leake has not been able to pitch late into games, having gone more than six innings only once since May 11. He allowed two earned runs in six innings of work his last time out, when he picked up his third win of the season.
Cubs: Kyle Hendricks will make his 12th start of the season when the clubs play the third game of their four-game series. Hendricks is coming off a win over the Nationals in which he gave up two earned runs over five innings. It'll be his fifth start this season at Wrigley Field, and he's still looking for his first win at home.
Greg Garno is an associate reporter for MLB.com. Carrie Muskat is a reporter for MLB.com. She writes a blog, Muskat Ramblings. You can follow her on Twitter @CarrieMuskat and listen to her podcast. This story was not subject to the approval of Major League Baseball or its clubs.