Manager Bud Black explained that this move gives Despaigne a few extra days of rest following his eight-inning start on Sunday against the Pirates, the longest outing this season by any starter.
It also serves to get Cashner back to the mound faster after a four-inning start against the Mets on Wednesday.
"We'll give Despi a few extra days … we thought it would be good to give him a few extra days and we thought it would be good to get Cashner back on the mound as soon as possible," Black said.
The decision to push Despaigne back to Sunday aligns his start with Brandon Morrow, who is on a Minor League rehabilitation assignment with Double-A San Antonio. On Sunday, Morrow will make his second and final start with the Missions, throwing approximately 80 pitches.
The Padres could then pick between Morrow or Despaigne to start when their turn rolls around on June 12 against the Dodgers at Petco Park. Despaigne has been filling in for Morrow while he has been on the disabled list with inflammation in his right shoulder.
Since filling in for Morrow, Despaigne is 1-3 with a 5.79 ERA in five starts, though he's allowed a combined three earned runs in his last starts covering 20 innings.
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter and listen to his podcast. This story was not subject to the approval of Major League Baseball or its clubs.