At first, Cespedes' exit looked like something worse. He had just fouled a ball off his foot in the second inning before striking out swinging at a Jesse Hahn changeup, then walked back to the clubhouse. But the illness was more painful than the foot.
Cespedes told MLB.com's Alejandro Zúñiga after the game that he felt ill in the first inning.
"I threw up and I felt a little lightheaded, but I'm good now," Cespedes said.
Cespedes entered the day batting .286 with seven home runs and 28 RBIs. Daniel Fields made his Major League debut to fill in and committed an error on a ground-ball single a couple of innings later before doubling and scoring in the ninth.
Jason Beck is a reporter for MLB.com. Read Beck's Blog, follow him on Twitter @beckjason and listen to his podcast. This story was not subject to the approval of Major League Baseball or its clubs.