Ryan Zimmerman (Nationals): The first baseman will seek to improve on his impressive lifetime .308/.391/.499 slash line against lefties when he faces Blue Jays southpaw Mark Buehrle. Zimmerman could be part of a productive lineup, as the Nats rank fifth in the Majors with 228 runs scored.
Ian Desmond (Nationals): With four homers and 15 RBIs across 200 at-bats this season, Desmond could have an affordable DraftKings price tag on Wednesday, when he faces Buehrle (1.36 WHIP since the outset of 2013). Notably, the shortstop owns career splits that include a .273/.323/.443 slash line against left-handers.
Wilson Ramos (Nationals): The catcher could be part of a Nationals stack against Buehrle due to his career .802 OPS against lefty pitchers (.721 vs. righties). Having posted a 4.97 ERA and a 1.39 WHIP this season, Buehrle could struggle against the Nats' high-scoring lineup.
Giancarlo Stanton (Marlins): With a lifetime .289/.384/.598 slash line against lefties, Stanton has proven to be among the best in baseball during those matchups. The outfielder could reach base often or display his power against Cubs lefty Jon Lester, who has a 1.31 WHIP this season.
Martin Prado (Marlins): Prado has long fared best vs. left-handers, against whom he has posted a lifetime .824 OPS (.739 vs. right-handers). The third baseman -- who can also be rostered at second base in DraftKings contests -- could be a cost-effective option against Lester. As a result, those who use Prado on Wednesday may have additional DraftKings funds to appropriate to the attractive ace starters on the Wednesday docket.
Adrian Gonzalez (Dodgers): The first baseman could improve on his impressive .912 career OPS against right-handers (.774 vs. lefties) when he leaves his spacious home park to face Rockies righty Chad Bettis (career 1.61 WHIP) at hitter-friendly Coors Field.
Andre Ethier (Dodgers): Ethier has accumulated notable career splits, with an .892 OPS against right-handers that exceeds his .641 mark vs. lefties. The outfielder could drive in multiple runs against Bettis (career 5.77 ERA) and benefit from facing a Rockies club that ranks 26th in the Majors with a .674 defensive efficiency ratio.
Joc Pederson (Dodgers): During his brief career, Pederson has thrived against right-handers to the tune of an .882 OPS (.811 vs. lefties). The speedy outfielder could contribute in multiple ways at an offense-inducing road park, which would make him an integral part of a Dodgers stack against Bettis.
DJ LeMahieu (Rockies): The second baseman could improve on his season-to-date .335 average when he brings his career .705 OPS against right-handers (.667 vs. lefties) into a matchup with Dodgers righty Mike Bolsinger (career 1.35 WHIP). Since joining the Rockies at the outset of the 2012 season, LeMahieu has posted a .782 OPS at Coors Field in comparison to a .617 mark during road contests.
Nick Hundley (Rockies): Since joining the Rockies at the outset of this season, Hundley has posted a .931 OPS at hitter-friendly Coors Field (.677 on the road). He could provide DraftKings participants with a productive catcher when he puts his lifetime .726 OPS against right-handers (.575 vs. lefties) to the test during a home contest against Bolsinger.
Adam Jones (Orioles): Jones could improve on his career .284/.320/.473 slash line against right-handers when he faces Astros righty Lance McCullers, who will be making his fourth Major League start after compiling just six Minor League appearances above the Class A Advanced level.
Jimmy Paredes (Orioles): With a .312 average, six homers and 25 RBIs across 157 at-bats, Paredes has made great improvements this season. He could continue to rake from a premium lineup position when he brings his career .737 OPS against right-handers (.449 vs. lefties) into a matchup with the inexperienced McCullers.
Chris Davis (Orioles): Since the start of his 2012 breakout season, Davis has registered a game-changing .892 OPS against right-handers as opposed to a .761 mark vs. lefties in that span. The first baseman could be part of an Orioles stack against McCullers, who has produced a 1.33 WHIP across his initial three Major League starts after posting a 1.36 mark in the Minors.
Chris Sale (White Sox): Sale has regained his dominant 2014 form (2.17 ERA, 0.97 WHIP) by compiling a 40:4 strikeout-to-walk ratio across his past four starts. The southpaw could continue to shut down the competition and earn a win when he faces the Rangers in a seemingly advantageous matchup against righty Nick Martinez (career 4.67 FIP).
Corey Kluber (Indians): DraftKings participants will struggle to resist Kluber, who has accumulated a 50:2 strikeout-to-walk ratio across his past four starts. Arguably the hottest pitcher in baseball at the moment, the righty could continue to compile difference-making statistics when he plies his trade at spacious Kauffman Stadium.
James Shields (Padres): Shields has increased his strikeout rate significantly in the National League, as he has accumulated 88 K's across 68 1/3 innings this season. The workhorse could continue to combine plenty of whiffs with quality frames on Wednesday, when he works at his pitcher-friendly home park against a Mets lineup that ranks 29th in the Majors with a .653 OPS against right-handers.
Dan Haren (Marlins): Haren has posted a 3.03 ERA and a 1.04 WHIP this season, and his mediocre 6.2 K/9 rate may not be an issue on Wednesday, when he faces a Cubs lineup that leads the Majors with 483 whiffs. The right-hander could thrive at his pitcher-friendly home park, having allowed just five runs across five starts at that venue since joining Miami.
All statistics are accurate through the completion of Monday's games.
This story was not subject to the approval of Major League Baseball or its clubs.