The Twins jumped out to a four-run lead in the first against Blue Jays lefty Mark Buehrle, but he settled down from there to throw a complete game to halt Minnesota's win streak at five games.
"They got five runs on two swings," Twins manager Paul Molitor said. "We just couldn't find a way to add on to our initial lead. And as for as Perkins, we brought him in to a tie game, which we haven't had him do much. He threw a couple close pitches on the walk to [Russell] Martin and then Chris got a fastball down where he can handle it and hit it into the bullpen."
May was staked to the early lead, but couldn't hold it, as the rookie struggled with his command and fell behind hitters throughout the rainy night that saw the game's start delayed by 61 minutes. Donaldson has been one of the hottest hitters in baseball this year, and simply didn't miss on a first-pitch changeup from May in the fifth to tie the game.
"The big mistake was the changeup up to Donaldson," May said. "That was the one that got me. Up to that point, I was playing with fire all game being behind guys."
Perkins, meanwhile, entered with a 1.19 ERA and 18-for-18 in save opportunities, but walked Martin to lead off the ninth before serving up the go-ahead homer to his former teammate on a first-pitch fastball.
"Obviously, Perk's going to challenge," said Colabello, who played with the Twins for parts of the last two seasons. "I've seen him pitch for a couple years now. I was looking heater, trying to stay aggressive, obviously don't want to get behind against a guy like him."
The home runs are ultimately what did the Twins in, but the offense didn't help, as Buehrle faced the minimum after giving up an RBI single to Kurt Suzuki in the first inning.
"When we get guys on we're usually scoring them but he kinda shut us down and we didn't have too many runners in scoring positon after the first," third baseman Trevor Plouffe said. "That's how we do our damage. That's a team over there that hits three-run homers and we don't really do that."
Rhett Bollinger is a reporter for MLB.com. Read his blog, Bollinger Beat, follow him on Twitter @RhettBollinger and listen to his podcast. This story was not subject to the approval of Major League Baseball or its clubs.