Ryan Howard (Phillies): With 10 homers and a .256 batting average across 160 at-bats, the first baseman has enjoyed a resurgence this season. Howard will bring his career .951 OPS against right-handers (.730 vs. lefties) into a matchup with Rockies righty Chad Bettis (career 6.29 ERA, 1.74 WHIP) at hitter-friendly Citizens Bank Park.
Prince Fielder (Rangers): The first baseman -- who has hit .368 with 10 homers this season -- has handled right-handers to the tune of a career .297/.409/.557 slash line. Fielder could reach base often against Red Sox righty Steven Wright, who has compiled just 56 1/3 Major League innings.
Shin-Soo Choo (Rangers): Choo has accumulated notable career splits, with a .905 OPS against right-handers that exceeds his .674 mark vs. lefties. The outfielder -- who has posted a lifetime .381 on-base percentage -- could reach often against Wright (career 1.33 WHIP).
Pablo Sandoval (Red Sox): With a lifetime .305/.359/.494 slash line against righties, the third baseman could be in position to thrive at a hitter-friendly road venue against Rangers righty Yovani Gallardo (career 1.30 WHIP).
Jose Altuve (Astros): With a lifetime .881 OPS against lefty hurlers (.695 vs. righties), the second baseman could reach base often against White Sox left-hander Carlos Rodon, the owner of a 1.84 WHIP in his young career. And if he were to find his way to first base, Altuve -- who has swiped 71 bags since the outset of the 2014 season -- would be a candidate to steal.
Evan Gattis (Astros): A possible difference-making catcher option, Gattis has accumulated 10 homers and 30 RBIs across 165 at-bats this season. The 28-year-old -- who has compiled a lifetime .502 slugging percentage vs. lefties -- could drive in multiple runs against Rodon (4.03 ERA).
Rajai Davis (Tigers): Davis has compiled pronounced career splits, with an .808 OPS against lefties in comparison to a .646 mark vs. right-handers. With southpaw Hector Santiago (career 1.34 WHIP) on the mound against Detroit, the Tigers outfielder could score multiple runs. Moreover, he could swipe a bag against catcher Chris Iannetta, who struggles to thwart would-be basestealers.
Ian Kinsler (Tigers): The second baseman -- who has recorded a lifetime .877 OPS against left-handers, as opposed to a .760 mark vs. righties -- could be part of a Tigers stack vs. Santiago. Several Tigers have typically done their best work against southpaws, and the club ranks second in the Majors with a .794 OPS in those matchups this season, so Detroit's lineup could put together a strong offensive performance against Santiago.
Brian Dozier (Twins): With nine homers and 37 runs scored across 178 at-bats, the second baseman has helped DraftKings participants on a number of occasions this season. On Friday, Dozier could spark the Twins lineup when he seeks to increase his lifetime .859 OPS against left-handers (.677 vs. righties) at the expense of Blue Jays southpaw Mark Buehrle (5.13 ERA, 1.51 WHIP in 2015).
Trevor Plouffe (Twins): DraftKings participants could stack Dozier with Plouffe in hopes that the latter can drive in the former on multiple occasions. The third baseman has registered a lifetime .835 OPS against left-handers (.691 vs. righties), and Buehrle has produced a 1.37 WHIP since joining the Blue Jays at the outset of the 2013 season.
Billy Butler (A's): The slugger could excel against Yankees lefty Chris Capuano, who has posted a 4.41 ERA and a 1.42 WHIP since the outset of the 2013 season. Butler has accumulated notable lifetime splits, with a .910 OPS against lefties in comparison to a .765 mark vs. right-handers, while Capuano in his career has allowed righty hitters such as Butler to compile an .800 OPS (.651 OPS allowed to lefty hitters).
Jason Kipnis (Indians): Kipnis could spark the Indians offense by reaching base often and scoring multiple runs when he takes his career .805 OPS against right-handers (.665 vs. lefties) into a matchup with Mariners righty Taijuan Walker (7.33 ERA, 1.84 WHIP in 2015).
Michael Brantley (Indians): Since the outset of his 2014 breakout season, the outfielder has registered a game-changing .331/.389/.523 slash line against right-handers. He could be part of an Indians stack -- joining Kipnis and Brandon Moss -- against the struggling Walker.
Matt Harvey (Mets): After allowing seven runs during his most recent start, the dominant right-hander could return to top form when he faces a Marlins lineup that ranks 27th in the Majors with a .665 OPS against right-handers.
Dan Haren (Marlins): DraftKings participants who do not select Harvey could opt for his mound opponent on Friday. Haren -- who has compiled a 3.09 ERA and a 1.08 WHIP this season -- could be a serviceable second starter when he works at a pitcher-friendly road venue against a Mets lineup that ranks 28th in the Majors with a .644 OPS against right-handers.
Trevor Bauer (Indians): Bauer has allowed three runs across 22 1/3 innings during his past three starts, which has helped improve his season-to-date stats (3.02 ERA, 1.16 WHIP). The high-strikeout hurler could accumulate whiffs and quality frames at spacious Safeco Field, with a victory also well within reach if Cleveland's lineup can score several runs against the struggling Walker.
Sonny Gray (A's): Having registered a 1.77 ERA and a 1.00 WHIP this season, the righty could continue to accumulate difference-making numbers when he faces the Yankees at his spacious home park. Gray could receive a win for a quality effort during this seemingly advantageous matchup against Capuano.
All statistics are accurate through the completion of Wednesday's games.