Bolsinger, the rotation replacement for the injured Brandon McCarthy, allowed a single to Yangervis Solarte to lead off the game, then retired the next 23 batters. He is 3-0 with an 0.71 ERA after opening the season at Triple-A. Kenley Jansen got the save, pitching in back-to-back games for the first time since February foot surgery.
"I'm not sure how many curveballs he threw, but he threw a lot of them. He threw them at the top of the zone, he threw them at the bottom of the zone, threw them in and away. It was a ton of curveballs in good spots," said Padres manager Bud Black.
Pederson, who won Friday night's game with an eighth-inning homer, led off the Dodgers' first inning with his 12th home run of the year off Ian Kennedy. The Dodgers also scored on Justin Turner's RBI double in the sixth inning.
The loss marked the eighth time this season -- and sixth time this month -- the Padres have been shut out.
MOMENTS THAT MATTERED Two-out rally: The Dodgers doubled their lead in the sixth inning on a two-out single by Adrian Gonzalez and a double to left-center by Turner. The Padres helped on the play, as left fielder Justin Upton fumbled the ball on the warning track and his throw in missed the cutoff.
Smooth debut for Middlebrooks: Padres shortstop -- that's right, shortstop -- Will Middlebrooks had a fairly uneventful night in his first professional start at shortstop. He handled the only ball hit to him cleanly and made a strong throw on Turner's ground ball in the fourth inning.
Slow start, fast finish: Kennedy allowed the leadoff home run to Pederson and, in the second inning, settled into a nice groove. He retired 13 consecutive hitters at one point before allowing a run in the sixth inning. He gave the Padres their fifth consecutive quality start. He struck out Andre Ethier with a runner on second to end the sixth.
"To give our team six solid innings, I was happy with that," Kennedy said. "I was happy to not give up many runs, but you've got to tip your cap to Bolsinger. He pitched a great game and shut our hitters down."
"Guys are trying, they might be pressing a little bit. Everybody wants to be the guy who helps us snap out of it." -- Black on the Padres offensive malaise, as they've been shut out six times in their last 18 games.
"That was a bummer because even driving to the ballpark, I was thinking, this game has no-hitter written all over it." -- Dodgers catcher A.J. Ellis joking about Solarte's single that led off the game.
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Pederson already has tied the club rookie record for leading off the game with a home run (three), set by Johnny Frederick in 1929.
To be sure it was a frustrating night for the Padres and, in particular, Upton, who was ejected by home plate umpire Clint Fagan in the top of the eighth inning after he struck out looking against Bolsinger. Upton was well inside the dugout when Fagan ejected him. It was his first ejection of the season.
WHAT'S NEXT Padres:James Shields gets the start for the Padres in the series finale at 1:10 p.m. PT. Other than the Major League-leading 14 home runs he's allowed, Shields has been everything the Padres have hoped for when they signed him in February. His 75 strikeouts lead the National League.
Dodgers:Carlos Frias will make his first start against San Diego, but his relief performances have been solid against the Padres -- one hit in three scoreless innings.
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter and listen to his podcast. Ken Gurnick is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.