Adrian Beltre (Rangers): Because Beltre is hitting .259 with five homers and 15 RBIs this season, he could have a reduced DraftKings price tag when he brings his career .290/.363/.488 slash line against lefties into a matchup with Yankees southpaw CC Sabathia. The third baseman could rip a round-tripper at hitter-friendly Yankee Stadium, as Sabathia has allowed 46 homers across 48 starts since the outset of the 2013 season.
Nelson Cruz (Mariners): The Major League home run leader could put a ball into the outfield seats on Saturday, when he hits away from spacious Safeco Field and faces lefty Mark Buehrle at homer-happy Rogers Centre. The outfielder has compiled a lifetime .920 OPS against left-handers (.814 vs. righties), and Buehrle has posted a 5.36 ERA this season.
Mike Zunino (Mariners): Because Zunino is hitting .175 this season, he could be an economical addition to DraftKings lineups. The catcher has produced a career .700 OPS against left-handers (.614 vs. righties), and Buehrle has compiled a 1.37 WHIP since joining the Blue Jays at the outset of the 2013 season.
Adam LaRoche (White Sox): The first baseman could drive in multiple runs at his hitter-friendly home park when he faces Twins righty Trevor May on Saturday. LaRoche has posted a career .841 OPS against right-handers (.714 vs. lefties), and May has compiled a lifetime 6.67 ERA and 1.64 WHIP.
Adam Eaton (White Sox): The outfielder, who has accumulated balanced career splits, could reach base often and score multiple runs against May, who has posted a 5.15 ERA and a 1.47 WHIP this season. Eaton could also swipe a base, as Twins No. 1 catcher Kurt Suzuki sometimes struggles to thwart opposing basestealers.
Jose Altuve (Astros): Altuve has proven to be among the best in baseball when facing lefties, against whom he has posted a career .351/.394/.485 slash line. The second baseman could reach base often and score multiple runs against Tigers southpaw Kyle Lobstein (career 4.32 ERA, 1.33 WHIP).
Dee Gordon (Marlins): With a .386 batting average, 12 steals and 23 runs scored, Gordon has been among the most productive second basemen in the Majors this season. He could continue to thrive on Saturday, when he brings his lifetime .709 OPS against right-handers (.617 vs. lefties) into a matchup with Orioles righty Mike Wright, who will be making his second Major League start.
Dustin Pedroia (Red Sox): The second baseman could collect multiple hits at his home park when he brings his career .305/.390/.458 slash line against southpaws into a matchup with Angels lefty C.J. Wilson (career 1.32 WHIP). In his career, Wilson has allowed right-handed hitters such as Pedroia to compile a .721 OPS (.557 allowed to lefty hitters).
Anthony Rizzo (Cubs): The first baseman could rip a round-tripper at homer-happy Chase Field when he brings his lifetime .837 OPS against right-handers (.753 vs. lefties) into a matchup with righty Rubby De La Rosa (career 4.28 ERA, 1.38 WHIP).
Anthony Gose (Tigers): The speedy outfielder could continue to thrive as a leadoff hitter when he puts his career .699 OPS against right-handers (.530 vs. lefties) on the line against Astros righty Lance McCullers. The 21-year-old hurler will be making his second career start after posting a lifetime 1.36 WHIP in the Minors.
Miguel Cabrera (Tigers): The first baseman could improve on his lofty lifetime .321/.387/.564 slash line against right-handers at the expense of the inexperienced McCullers, who jumped straight from Double-A to the Majors earlier this week.
Kevin Kiermaier (Rays): Kiermaier has compiled notable career splits with an .806 OPS against right-handers in comparison to a .544 mark vs. lefties. The outfielder could reach base often and score multiple runs when he faces A's righty Kendall Graveman, who registered an 8.27 ERA and a 2.02 WHIP in his first four career Major League starts this season.
James Loney (Rays): The first baseman has been regularly hitting near the heart of the lineup, and he will bring a career .787 OPS against right-handers (.660 vs. lefties) into a matchup with Graveman. In his brief career, the A's righty has allowed left-handed hitters such as Loney to compile a 1.021 OPS (.720 OPS allowed to righty hitters).
Corey Kluber (Indians): With a 30:1 strikeout-to-walk ratio across his past two starts, the right-hander has regained his Cy Young form from a year ago. Kluber could accumulate whiffs, quality frames and a win when he works at home against the Reds and Anthony DeSclafani (career 4.85 ERA, 1.33 WHIP).
Chris Sale (White Sox): During his past two starts, the ace left-hander has returned to his dominant 2014 form (2.17 ERA, 0.97 WHIP) by striking out 18 and allowing three runs across 16 innings. Sale could succeed against a Twins lineup that ranks 10th in the American League with a .698 OPS, and he could pick up a win if the opposing starter May cannot improve on his career 6.67 ERA.
A.J. Burnett (Pirates): Yet to allow more than two runs in a start this season, the right-hander has posted a 1.38 ERA with a 1.15 WHIP in 52 innings. Burnett could continue to thrive on Saturday, when he works at his pitcher-friendly home park against a Mets lineup that ranks 28th in the Majors with a .631 OPS against right-handers.
Mike Bolsinger (Dodgers): DraftKings participants may need to look for an economical second starter with so many aces on the Saturday docket, and Bolsinger could suffice. The right-hander has posted a career 4.39 ERA and a 1.46 WHIP, but he has allowed just two runs across three starts this season. Backed by the third-highest-scoring offense in the National League (186 runs) and pitching at his spacious home park, Bolsinger could deliver a quality outing and a win vs. the Padres.
All statistics are accurate through the completion of Thursday's games.