Bryce Harper (Nationals): Harper has wielded a potent bat this season, with 15 homers, 38 RBIs and a .333 batting average through 41 games played. The outfielder could improve on his lifetime .911 OPS against right-handers (.726 vs. lefties) when he faces Phillies righty Sean O'Sullivan (career 1.54 WHIP).
Denard Span (Nationals): The outfielder could reach base often and score multiple runs when he hits out of his customary leadoff spot against O'Sullivan, who has a career 5.72 ERA. Span -- who swiped 31 bases last season -- could also steal a bag, as Phillies No. 1 catcher Carlos Ruiz sometimes struggles to control baserunners.
Brian McCann (Yankees): The catcher could improve on his career .828 OPS against right-handers (.750 vs. lefties) when he faces Rangers righty Colby Lewis (lifetime 4.75 ERA, 1.38 WHIP) at offense-inducing Yankee Stadium.
Didi Gregorius (Yankees): The shortstop could be an economical option for DraftKings participants when he brings his lifetime .711 OPS against right-handers (.490 vs. lefties) into a matchup with Lewis at a hitter-friendly venue. As a big leaguer, Lewis has allowed such left-handed hitters as Gregorius to compile an .826 OPS (.722 OPS allowed to righty hitters).
Seth Smith (Mariners): Smith has registered notably contrasting career splits, with an .837 OPS against right-handers that exceeds his .606 mark vs. lefties. The outfielder could drive in multiple runs when he leaves his pitcher-friendly home park to hit at offense-inducing Rogers Centre against righty Marco Estrada (lifetime 4.20 ERA).
Robinson Cano (Mariners): Cano could improve on his impressive lifetime .318/.365/.523 slash line against righties at the expense of Estrada (career 1.4 HR/9 rate). The second baseman has dealt with a notable power dip since relocating to Seattle prior to the 2014 season, but he could put a ball into the outfield seats at hitter-friendly Rogers Centre.
Adam LaRoche (White Sox): LaRoche could smack a homer on Friday, when he faces the Twins' fly-ball-prone righty Phil Hughes at hitter-friendly U.S. Cellular Field. The first baseman has registered a career .841 OPS against right-handers (.715 vs. lefties), and Hughes has a lifetime 1.2 HR/9 rate.
Conor Gillaspie (White Sox): Gillaspie has produced pronounced career splits, with a .762 OPS against right-handers that notably exceeds his .512 mark vs. lefties. He could provide DraftKings participants with a cost-effective third baseman when he faces Hughes, who has a career 4.34 ERA and a 4.76 mark this season.
Freddie Freeman (Braves): Having posted an .878 OPS against right-handers (.741 vs. lefties) and an .871 OPS at Turner Field (.797 on the road) during his big league tenure, the first baseman could reach base often in a home matchup against Brewers righty Wily Peralta (career 1.36 WHIP).
Carlos Gonzalez (Rockies): Gonzalez has a .299/.364/.544 slash line against righties and a 1.005 OPS at hitter-friendly Coors Field during his career. Thus he could have considerable success at the expense of Giants right-hander Ryan Vogelsong (career 1.40 WHIP), who will face the Rockies in Colorado.
Angel Pagan (Giants): Pagan could collect multiple hits or score runs from his premium lineup spot when he vacates pitcher-friendly AT&T Park to face righty Kyle Kendrick (lifetime 4.51 ERA, 1.37 WHIP) at offense-inducing Coors Field. The outfielder -- who is a career .295 hitter against righties -- could also swipe a base, as catcher Nick Hundley sometimes struggles to control opposing baserunners.
Brandon Belt (Giants): The first baseman could display his extra-base power when brings his lifetime .815 OPS against right-handers (.753 vs. lefties) into a matchup with Kendrick at a homer-happy venue. The righty hurler has struggled this season to the tune of a 6.70 ERA and a 1.51 WHIP. Belt could also benefit from putting the ball into play against a Rockies defense that ranks 28th in the Majors with a .663 defensive efficiency ratio.
Michael Pineda (Yankees): With a 3.31 ERA, a 1.10 WHIP and 55 strikeouts across 51 2/3 innings this season, the right-hander could be emerging as an ace. On Friday, when he faces a Rangers lineup that ranks 26th in the Majors with a .656 OPS against righties, Pineda could be a difference-maker for DraftKings participants. And with Lewis toeing the rubber for Texas, Pineda has a good chance to emerge from this contest with a victory.
Gerrit Cole (Pirates): Having compiled a 2.40 ERA and 53 strikeouts across 48 2/3 innings this season, the right-hander seems to be realizing his immense potential. He could continue to dominate the competition when he faces a Mets lineup that ranks 29th in the Majors with a .628 OPS against right-handers.
Max Scherzer (Nationals): Scherzer -- who has compiled a 1.75 ERA and a 0.92 WHIP in 2015 -- could continue to dominate the Senior Circuit when he faces a Phillies lineup that ranks last in baseball with 3.2 runs per game. He could turn a quality outing into a win if his teammates score several runs against O'Sullivan.
Ubaldo Jimenez (Orioles): Jimenez has reemerged as a productive starter by posting a 2.43 ERA, a 1.03 WHIP and 38 strikeouts across 40 2/3 innings this season. He could thrive when he leaves hitter-friendly Camden Yards to work at spacious Marlins Park against a Marlins lineup that ranks 25th in the Majors with a .659 OPS against right-handers.
Zack Greinke (Dodgers): Since joining the Dodgers at the outset of the 2013 season, Greinke has compiled a 2.53 ERA overall and a 2.37 mark at his pitcher-friendly home park. He could continue to dominate at his home venue when he faces a Padres lineup that possesses several key members who have traditionally fared best against lefties.
All statistics are accurate through the completion of Wednesday's games.
This story was not subject to the approval of Major League Baseball or its clubs.