It will mark Zobrist's first game action since April 24, as he has been on the disabled list since undergoing arthroscopic surgery to repair a meniscus tear in his left knee.
Zobrist tested out his legs with some baserunning on the field at the Coliseum before Sunday's contest and made it through with no setbacks.
In his first season with the A's, Zobrist is batting .240/.304/.400 with a homer, five doubles and eight RBIs in 14 games.
The versatile veteran began the season as a corner outfielder while the A's dealt with injuries, but settled into the starting second baseman's role before going down with his injury.
Alex Espinoza is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.