Chris Davis (Orioles): With a lifetime .261/.337/.513 slash line against right-handers, the first baseman has the necessary blend of power and patience to thrive against Blue Jays righty Aaron Sanchez at cozy Camden Yards. Sanchez has compiled a career 4.25 FIP, and he has walked 34 batters across 65 1/3 career innings.
Adam Jones (Orioles): In his career, the outfielder has enjoyed great success against right-handers (.798 OPS) and at his hitter-friendly home park (.832 OPS). Because the Orioles are third in the Majors with a .778 OPS against right-handers, Jones could be part of a productive offense on Wednesday.
Anthony Gose (Tigers): Gose could reach base often and score multiple runs on Wednesday, when the outfielder brings his career .693 OPS against right-handers (.517 vs. lefties) into a matchup with Twins righty Ricky Nolasco (career 4.52 ERA, 1.32 WHIP).
Miguel Cabrera (Tigers): The first baseman -- who can also be used at third base in DraftKings lineups -- could improve on his impressive lifetime .321/.387/.564 slash line against right-handers when he faces Nolasco on Wednesday. Nolasco has posted a 5.65 ERA and a 1.55 WHIP since joining the Twins at the outset of the 2014 season.
Todd Frazier (Reds): Frazier could improve on his career .266/.328/.488 slash line against left-handers on Wednesday, when the third baseman faces Stults (career 1.34 WHIP) at hitter-friendly Great American Ball Park.
Freddie Freeman (Braves): Freeman has long fared best against right-handers, against whom he has compiled a lifetime .882 OPS (.748 vs. lefties). The first baseman could reach base often and drive in multiple runs Wednesday, when he faces Reds righty Raisel Iglesias, who will be making his second Major League start.
Nick Markakis (Braves): The outfielder will bring a career .291/.365/.449 slash line against right-handers into a matchup with the inexperienced Iglesias. In an offense-inducing road environment, Markakis could reach base often or score multiple runs from his customary spot at the top of the lineup.
Eric Hosmer (Royals): The first baseman could thrive away from his spacious home park on Wednesday, when he faces Rangers righty Yovani Gallardo (career 1.30 WHIP) at hitter-friendly Globe Life Park in Arlington. Hosmer has compiled a lifetime .796 OPS against right-handers in comparison to a .676 mark against lefties.
Mike Moustakas (Royals): Hitting .319 this season, Moustakas could improve on his lifetime .700 OPS vs. righties (.619 against southpaws) during a game against the righty Gallardo. For his part, the third baseman has ripped 45 of his 55 career round-trippers when a right-hander is on the mound.
Wilin Rosario (Rockies): Recently recalled from the Minors, the slugger should find his way into the Wednesday lineup when Colorado competes at an American League venue against Angels lefty Hector Santiago. Having compiled an impressive career 1.015 OPS against left-handers (.711 vs. righties), Rosario could thrive in this tilt.
Ryan Braun (Brewers): The outfielder could improve on a lofty lifetime 1.031 OPS against left-handers (.877 vs. righties) on Wednesday, when he greets White Sox southpaw Jose Quintana at hitter-friendly Miller Park. Quintana owns an unimpressive career 1.27 WHIP and has posted a 1.41 mark this season.
Mike Trout (Angels): Trout could merit a large DraftKings expenditure on Wednesday, when he brings his career .965 OPS against right-handers (.901 vs. lefties) into a matchup with Rockies righty Jordan Lyles (career 1.44 WHIP).
Matt Harvey (Mets): Coming off Tommy John surgery, Harvey is sitting at 5-1 with a 2.72 ERA and a 0.96 WHIP after six starts in 2015. The right-hander has struck out 38 batters across 39 2/3 innings, and he could continue to rack up whiffs on Wednesday against a Cubs lineup that leads the Majors with 312 K's.
Francisco Liriano (Pirates): Liriano has pitched well this season, with a 2.79 ERA and a 0.93 WHIP across six starts to show for his work. On Wednesday, the left-hander could continue to compile outstanding results vs. a Phillies lineup that ranks last in the Majors in OPS (.616) and runs per game (2.85). And with a career 9.2 K/9 rate, Liriano could also deliver plenty of strikeouts for DraftKings participants.
Kyle Lobstein (Tigers): DraftKings participants seeking a low-cost second starter could consider Lobstein against the Twins. The left-hander has compiled a career 3.73 ERA, which factors in his 3.00 mark from this season. If the Tigers' deep lineup can score several runs against Nolasco, Lobstein could have the run support he needs to come away with a win.
Carlos Frias (Dodgers): The right-hander has compiled a career 5.00 ERA that masks a respectable 3.45 FIP. On Wednesday, he will work at his pitcher-friendly home park against a Marlins lineup that ranks 20th in baseball with a .690 OPS against right-handers despite logging a lofty .329 BABIP in those matchups. Also of note: Frias could receive ample run support from an offense that will bring a Major League-best .851 OPS against right-handers into a matchup with Marlins righty Jarred Cosart.
All statistics are accurate through the completion of Monday's games.