A back and forth battle ensued between the two clubs during their seven meetings this season, with four of the games being decided by two runs or fewer.
Boston and Chicago split the first four-game series at U.S. Cellular Field before the Red Sox took the first two of three at Fenway to secure the season series. With rain halting the final contest on Aug. 14, the two met up for one final meeting on Labor Day and the White Sox walked away victorious.
Here is a look at those seven games.
July 21 -- Red Sox 6, White Sox 5: The visiting Red Sox took the first of a four-game series with a solo home run by Manny Ramirez in the ninth inning to break a 5-5 tie. Chicago had jumped out to an early 4-1 lead on three long balls, but it was defensive errors that cost the White Sox late as Boston rallied to tie up the game and eventually secure the victory off those miscues.
July 22 -- White Sox 8, Red Sox 4: It looked to be another tight battle in Chicago with the two teams knotted at 1 heading into the bottom of the sixth. The White Sox bats broke out to score six runs in the inning on two three-run homers, one by A.J. Pierzynski and the other by Juan Uribe, for a 7-1 lead. Boston would attempt a rally in the ninth, scoring two runs, but couldn't mount a full assault.
July 23 -- Red Sox 3, White Sox 0: An early miscue by Sox pitcher Orlando Hernandez to Ramirez would prove costly as the Red Sox took a 2-0 lead in the first inning. The early deficit seemed to quiet the Chicago bats and though the team had offensive opportunities, it wasn't able to convert on any. Boston added one more run in the ninth off a Jason Varitek homer to secure the win.
July 24 -- White Sox 6, Red Sox 4: The heat was on the White Sox, both literally and figuratively, in the final game of the series. On a day where the thermometer read 100 degrees for first pitch, Chicago took a 6-3 lead into the ninth but Boston almost pulled off the comeback. Chicago reliever Damaso Marte walked two Red Sox in the ninth before Dustin Hermanson replaced him and gave up a hit to score one run. Hermanson then recorded two straight outs to pick up the save.
August 12 -- Red Sox 9, White Sox 8: Mark Buehrle had a forgettable outing at Fenway, giving up six runs on 12 hits over seven innings. The run Buehrle gave up in the seventh broke a 5-5 tie. The Red Sox would add three more in the eighth, but Chicago looked primed to knot it up again in the ninth. Paul Konerko and Tadahito Iguchi each homered off Curt Schilling to score three runs and pull within one, but Schilling struck out Aaron Rowand to end the threat.
August 13 -- Red Sox 7, White Sox 4: Chicago fell behind early in a rough outing for starter Jon Garland, who gave up five runs in 5 1/3 innings. While Garland struggled, Boston hurler Tim Wakefield dazzled with his knuckleball for six shutout innings until it disappeared after he came back from a 40-minute rain delay. Chicago scored two runs in the seventh off Wakefield to make it a 5-2 game, but Boston would score two more in the inning to pull away.
September 5 -- White Sox 5, Red Sox 3: Chicago made a one-day trek to Boston to make up the Aug. 14 contest that had been washed away by rain. Brandon McCarthy made it a worthwhile trip for the White Sox as the rookie tossed seven scoreless innings and gave up just three hits in his first outing at Fenway Park. McCarthy was helped out by an offense that scored four runs off Boston starter Schilling. Konerko led the Chicago offensive attack with a homer, a double and two runs scored.
Kelly Thesier is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.