In the first inning, Myers raced back to the warning track in straightaway center field as Evan Gattis of the Astros jumped on a pitch from Tyson Ross. Myers got to the wall and seemed to be well-positioned to make a catch.
The only problem was that the ball hit off the side of his glove, bounced atop the padded fence and rolled over for a two-run home run.
It was that kind of night for the Padres, who fell behind early and then were buried in a 14-3 loss to the Astros at Petco Park, their sixth loss in their past seven games.
"I checked the wall a couple times as I was running back," Myers said. "I got to the wall, found it and just missed the ball. I felt like I got back on that ball. When I jumped up, it hit the side of my glove.
"I thought I had it. I was on it the whole way. That's how it goes sometimes."
If that missed opportunity troubled Myers, it didn't stay with him long, as he led off the bottom of the first with a bunt single, stole second base and scored on a Yangervis Solarte RBI single.
Myers later added a solo home run, his fourth of the season. That gave him a team-leading 15 RBIs in 22 games. He's hitting .320 in his last 18 games with 14 of those 15 RBIs.
"Get in there, get going … not much time to think about it," Myers said of hitting leadoff.
While Myers doesn't fit the bill as a prototypical leadoff hitter, he appears to be settling into that spot for the Padres.
He had two hits Tuesday and reached on an error. He's currently hitting .287 and is tied for second in the big leagues in runs (17).
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.