The trend began with Pep Goodwin in 1914, and 80 other players in total had done it before Bryant. The most recent was fellow Chicago slugger Jose Abreu, who debuted in the cleanup spot for the White Sox on March 31 of last year.
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Other notable players to debut in the cleanup spot: Justin Morneau (June 10, 2003), Tim Salmon (Aug. 21, 1992), Pete Incaviglia (April 8, 1986), Rusty Staub (April 9, 1963), Hall of Famer Jim Bottomley (Aug. 18, 1922) and Hall of Famer Kiki Cuyler (Sept. 29, 1921)
Bryant, 23, has appeared in 181 Minor League games over the past three seasons, batting .327 with 49 doubles, 55 homers and 152 RBIs.
Joey Nowak is a reporter for MLB.com. Follow him on Twitter at @joeynowak. This story was not subject to the approval of Major League Baseball or its clubs.