But the righty got out of the jam, getting Desmond Jennings to pop up to keep the O's lead intact.
"I think some of the situations he was in last year, it all plays into it," manager Buck Showalter said of Gausman performing well in a relief role. "He's been exposed to a lot of things like that and it will play well.
"He was capable of throwing 70 pitches tonight, but I want him to take two days [off] and be back for us [on] Friday."
Gausman, who missed out on the fifth starter spot this spring, allowed a pair of runs in the following frame -- a Kevin Kiermaier two-run homer -- and ended up going 2 1/3 innings. He also hit an impressive 101 mph on the radar gun at Tropicana Field.
"I think last time I pitched was last Tuesday. I definitely had my rest," Gausman said. "I felt good. Also adrenaline, [the] first game out had something to do with it."
Brittany Ghiroli is a reporter for MLB.com. Read her blog, Britt's Bird Watch, and follow her on Facebook and Twitter @britt_ghiroli. This story was not subject to the approval of Major League Baseball or its clubs.