That will leave Mike Napoli on the bench, though his right-handed bat will almost certainly become a factor in the mid-to-late innings.
Ortiz didn't play first base at all during Spring Training, but playing defense after a long layoff is nothing new to him.
In three World Series (2004, '07 and '13), Ortiz played first base after several weeks of not playing defense. Not only that, but he held his own each time.
Ortiz will likely start two of the three games in Philadelphia.
The Red Sox will get the DH back for their second series of the season, which starts on Friday night at Yankee Stadium.
In fact, after the series in Philly, Boston won't lose the DH again until June 17 in Atlanta.
Ian Browne is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.