"They played well. We told them that if they played well and perform as things change throughout the course of the season, we'll see those guys in San Diego," manager Bud Black said of Thursday's moves, referring specifically to Medica and Almonte.
With Wednesday's moves, the Padres have 34 players in big league camp, though 32 are healthy. Pitchers Josh Johnson and Cory Luebke will begin the season on the disabled list as they are working their way back from Tommy John surgery.
Lane posted an 8.49 ERA in 11 2/3 innings, while Mateo had a 5.40 ERA in 10 innings. Both figure to be part of the staff in El Paso.
Pena, a versatile infielder, hit .267 in 30 at-bats. Medica hit .421 with four home runs and 12 RBIs in 38 at-bats. After a scorching start, Medica had one hit in his last 11 at-bats. Almonte hit .263 in 38 at-bats.
There's a good chance the Padres will wait until Saturday, when they play an exhibition game at Petco Park against the Mexico City Red Devils, before they make their final roster decisions.
Black has yet to announce who the Padres' fifth starter will be -- Brandon Morrow or Odrisamer Despaigne -- and is still sorting through how the bullpen and five-man bench will look when the team opens the season Monday against the Dodgers.
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.