In the top of the fifth, a pair of projected reserve infielders boosted San Diego some more. Clint Barmes hit a one-out solo homer to left field on a first pitch from DeSclafani. Following a pair of two-out hits, Yangervis Solarte blistered a 2-0 pitch for a three-run homer to right field to make it a 6-0 game.
"I was behind in the count and did not make good pitches and that happens," DeSclafani said. "Those are big league hitters, and they're going to capitalize on it. I'll try to be better."
It was the worst outing of spring for DeSclafani, who finished with six earned runs on seven hits over six innings. He walked one and struck out four.
Padres No. 4 starter Ian Kennedy made his first Cactus League start since March 20 against the Royals, because his previous outing was in a Minor League setting. Kennedy worked six scoreless innings with six hits, one walk and seven strikeouts.
In the fourth inning, the Reds had a chance to do damage with runners on second and third base and no outs, but they came up empty with two flyouts to right field sandwiching a strikeout.
Chris Dominguez put the Reds on the board with a two-out RBI single in the eighth, tying him for the team lead with 14 RBIs. The next batter, Skip Schumaker, drove in the Reds' second run, but he got thrown out after rounding first base.
Reds shortstop Kristopher Negron posted his 19th hit of spring with a ninth-inning ground-rule double, and he scored on a Joey Votto sacrifice fly.
Up next: With precious few roster spots left, pitching prospect Michael Lorenzen will have another chance to audition to make the team when he starts Tuesday for the Reds against the Brewers. First pitch from Maryvale is scheduled for 4:05 p.m. ET, live on MLB.TV. Lorenzen, a non-roster invitee, has a 1.64 ERA this spring, and he is trying to make the club as either the fifth starter or a long man in the bullpen.
Mark Sheldon is a reporter for MLB.com. Read his blog, Mark My Word, and follow him on Twitter @m_sheldon. This story was not subject to the approval of Major League Baseball or its clubs.