In the top of the fifth, a pair of projected reserve infielders boosted San Diego some more. Clint Barmes hit a one-out solo homer to left field on a first pitch from DeSclafani. Following a pair of two-out hits, Yangervis Solarte blistered a 2-0 pitch for a three-run homer to right field to make it a 6-0 game.
"I was behind in the count and did not make good pitches and that happens," DeSclafani said. "Those are big league hitters, and they're going to capitalize on it. I'll try to be better."
It was the worst outing of spring for DeSclafani, who finished with six earned runs on seven hits over six innings. He walked one and struck out four.
Padres No. 4 starter Ian Kennedy made his first Cactus League start since March 20 against the Royals, because his previous outing was in a Minor League setting. Kennedy worked six scoreless innings with six hits, one walk and seven strikeouts.
"I thought he threw some tight sliders today and some effective changeups," Padres manager Bud Black said of Kennedy. "He's a heavy-fastball usage guy, and it's a good one."
Kennedy, for one, says it's time to get out of Arizona and on to the regular season, which starts in exactly a week.
"You're noticing guys start to ramp it up," he said. "We're excited to get to Petco [Park] and San Diego."
In the fourth inning, the Reds had a chance to do damage with runners on second and third base and no outs, but they came up empty with two flyouts to right field sandwiching a strikeout.
Chris Dominguez put the Reds on the board with a two-out RBI single in the eighth, tying him for the team lead with 14 RBIs. The next batter, Skip Schumaker, drove in the Reds' second run, but he got thrown out after rounding first base.
Reds shortstop Kristopher Negron posted his 19th hit of spring with a ninth-inning ground-rule double, and he scored on a Joey Votto sacrifice fly.
Up next: Brandon Morrow gets the start at 7:05 p.m. PT on Tuesday against the Royals at the Peoria Sports Complex. It will be Morrow's first appearance since March 21, which is when he aggravated a blister on his right ring finger. Morrow is considered the favorite to win the fifth starter job, with Odrisamer Despaigne likely being a better fit for long relief on the 25-man roster. Manager Bud Black thought the blister issue had a direct effect on Morrow's last outing, when he allowed five runs on eight hits in 3 2/3 innings. Overall, though, his stuff has been good in camp. The game will be televised live by Fox Sports San Diego and broadcast on AM 1090.